Educational level as a cause of type 2 diabetes mellitus: Caution from triangulation of observational and genetic evidence
Sign Up to like & getrecommendations! Published in 2021 at "Acta Diabetologica"
DOI: 10.1007/s00592-021-01795-7
Abstract: Education might be causal to type 2 diabetes mellitus (T2DM). We triangulated cohort and genetic evidence to consolidate the causality between education and T2DM. We obtained observational evidence from the English Longitudinal Study of Ageing… read more here.
Keywords: genetic evidence; educational level; evidence; type diabetes ... See more keywords
Genetic evidence in tracking the origin of Ulva prolifera blooms in the Yellow Sea, China.
Sign Up to like & getrecommendations! Published in 2018 at "Harmful algae"
DOI: 10.1016/j.hal.2018.08.002
Abstract: Recurrent green tides have been recorded in the Yellow Sea for 11 consecutive years. The origin of floating green algae in the Yellow Sea, however, remains a subject of debate. Previous studies suggest that the… read more here.
Keywords: genetic evidence; china; ulva prolifera; yellow sea ... See more keywords
Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.33
Abstract: The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified hundreds of risk variants potentially implicated in the disease. Further, novel statistical methodology designed for polygenic architecture revealed more potential risk variants. This can… read more here.
Keywords: genetic evidence; integration; integration fast; evidence role ... See more keywords
Searching for genetic evidence of demographic decline in an arctic seabird: beware of overlapping generations.
Sign Up to like & getrecommendations! Published in 2022 at "Heredity"
DOI: 10.1038/s41437-022-00515-3
Abstract: Genetic data are useful for detecting sudden population declines in species that are difficult to study in the field. Yet this indirect approach has its own drawbacks, including population structure, mutation patterns, and generation overlap.… read more here.
Keywords: decline; arctic seabird; genetic evidence; population ... See more keywords
Development of a genetic priority score to predict drug side effects using human genetic evidence
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63762-y
Abstract: Many drug failures in clinical trials are due to inadequate safety profiles. We developed an in-silico side effect genetic priority score (SE-GPS) that leverages human genetic evidence to inform side effect risk for a given… read more here.
Keywords: genetic evidence; score; side; drug ... See more keywords
Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases
Sign Up to like & getrecommendations! Published in 2024 at "Nature Human Behaviour"
DOI: 10.1038/s41562-024-01970-0
Abstract: Loneliness—the subjective experience of social disconnection—is now widely regarded as a health risk factor. However, whether the associations between loneliness and multiple diseases are consistent with causal effects remains largely unexplored. Here we combined behavioural,… read more here.
Keywords: loneliness; genetic evidence; associations loneliness; risk ... See more keywords
Genetic evidence that a gut commensal bacterium can cause colorectal cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.12.014
Abstract: Our gastrointestinal tract is colonized by trillions of microbes. There is growing recognition that commensal bacteria can promote the development of colorectal adenomas and cancer. For example, bacterial plaques are strongly associated with adenomas in… read more here.
Keywords: genetic evidence; colorectal cancer; evidence gut; gut commensal ... See more keywords
Genetic evidence for several cryptic species within theScarturus elaterspecies complex (Rodentia: Dipodoidea): when cryptic species are really cryptic
Sign Up to like & getrecommendations! Published in 2018 at "Biological Journal of the Linnean Society"
DOI: 10.1093/biolinnean/bly154
Abstract: 1Lomonosov Moscow State University, Vorobievy Gory, 119992 Moscow, Russia 2Zoological Museum of Moscow State University, B. Nikitskaya 6, 125009 Moscow, Russia 3Slovenian Museum of Natural History, PO Box 290, 1001 Ljubljana, Slovenia 4Das Zoologische Forschungsmuseum… read more here.
Keywords: genetic evidence; several cryptic; evidence several; species within ... See more keywords
Genetic evidence for splicing-dependent structural and functional plasticity in CASK protein
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Genetics"
DOI: 10.1136/jmg-2023-109747
Abstract: Background Pontocerebellar hypoplasia (PCH) may present with supratentorial phenotypes and is often accompanied by microcephaly. Damaging mutations in the X-linked gene CASK produce self-limiting microcephaly with PCH in females but are often lethal in males.… read more here.
Keywords: genetic evidence; cask protein; function; vertebrate specific ... See more keywords
Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations
Sign Up to like & getrecommendations! Published in 2024 at "BMC Biology"
DOI: 10.1186/s12915-024-01854-9
Abstract: The underrepresentation of human genomic resources from Southern Chinese populations limited their health equality in the precision medicine era and complete understanding of their genetic formation, admixture, and adaptive features. Besides, linguistical and genetic evidence… read more here.
Keywords: genetic evidence; admixture; history; language ... See more keywords
Genetic Evidence for Protective Effects of Angiotensin-Converting Enzyme Against Alzheimer Disease But Not Other Neurodegenerative Diseases in European Populations
Sign Up to like & getrecommendations! Published in 2022 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000200014
Abstract: Background and Objectives Angiotensin-converting enzyme (ACE) inhibitors are a commonly prescribed class of medication used to treat heart failure, hypertension, and chronic kidney disease. However, previous observational studies have shown conflicting directions of associations between… read more here.
Keywords: ace expression; disease; alzheimer disease; ace ... See more keywords