Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory
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DOI: 10.1007/s10519-020-10011-1
Abstract: Two-pore channels (TPCs) constitute a small family of cation channels that are localized in membranes of endosomal and lysosomal compartments. Although their roles for vesicular fusion and endolysosomal trafficking have been investigated, our knowledge on… read more here.
Keywords: tpc1; tpc1 mice; learning memory; genetic inactivation ... See more keywords
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.
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DOI: 10.1038/s41418-020-00625-7
Abstract: RIP1 kinase is proposed to play a critical role in driving necroptosis and inflammation in neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS). Preclinical studies indicated that while pharmacological inhibition of RIP1 kinase can ameliorate axonal… read more here.
Keywords: kinase activity; kinase; rip1 kinase; pathology ... See more keywords