Obesity and cancer: A mechanistic overview of metabolic changes in obesity that impact genetic instability
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23048
Abstract: Obesity, defined as a state of positive energy balance with a body mass index exceeding 30 kg/m2 in adults and 95th percentile in children, is an increasing global concern. Approximately one‐third of the world's population… read more here.
Keywords: genetic instability; metabolic changes; cancer; obesity ... See more keywords
Bloom syndrome and the underlying causes of genetic instability.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2021.03.003
Abstract: Autosomal hereditary recessive diseases characterized by genetic instability are often associated with cancer predisposition. Bloom syndrome (BS), a rare genetic disorder, with read more here.
Keywords: genetic instability; syndrome underlying; bloom syndrome;
Up-regulation of mismatch repair genes MSH6, PMS2 and MLH1 parallels development of genetic instability and is linked to tumor aggressiveness and early PSA recurrence in prostate cancer
Sign Up to like & getrecommendations! Published in 2017 at "Carcinogenesis"
DOI: 10.1093/carcin/bgw116
Abstract: DNA mismatch repair (MMR) is integral to the maintenance of genetic stability. We aimed to evaluate the clinical impact of MMR gene expression in prostate cancer. The MMR genes MSH6, MLH1 and PMS2 were analyzed… read more here.
Keywords: genetic instability; prostate cancer; expression; cancer ... See more keywords
Oxidative damage within alternative DNA structures results in aberrant mutagenic processing
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf066
Abstract: Abstract Genetic instability is a hallmark of cancer, and mutation hotspots in human cancer genomes co-localize with alternative DNA structure-forming sequences (e.g. H-DNA), implicating them in cancer etiology. H-DNA has been shown to stimulate genetic… read more here.
Keywords: oxidative damage; alternative dna; dna; genetic instability ... See more keywords
Replication timing and genetic instability
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.ade4734
Abstract: Description Synchronized activation of DNA replication origins induces genetic instability in lymphoma Chromosomal translocations are promoted by DNA double-strand breaks (DSBs) that are joined inappropriately. They are common in cancer cells, and some are characteristic… read more here.
Keywords: translocation; replication; replication timing; myc ... See more keywords
Correlations between Risk Factors for Breast Cancer and Genetic Instability in Cancer Patients—A Clinical Perspective Study
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2017.00236
Abstract: Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are… read more here.
Keywords: genetic instability; risk factors; breast cancer; cancer ... See more keywords
Genetic instability-related lncRNAs predict prognosis and influence the immune microenvironment in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.926984
Abstract: Genome instability is a hallmark of cancer, and the function of lncRNAs in regulating genomic stability has been gradually characterized. However, the prognostic value of lncRNAs related to genetic instability has not been found in… read more here.
Keywords: instability; breast cancer; genetic instability; instability related ... See more keywords
Genetic Instability and Chromatin Remodeling in Spermatids
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10010040
Abstract: The near complete replacement of somatic chromatin in spermatids is, perhaps, the most striking nuclear event known to the eukaryotic domain. The process is far from being fully understood, but research has nevertheless unraveled its… read more here.
Keywords: genetic instability; dna; remodeling spermatids; chromatin ... See more keywords
Effects of Aging on Z-DNA-Induced Genetic Instability In Vivo
Sign Up to like & getrecommendations! Published in 2025 at "Genes"
DOI: 10.3390/genes16080942
Abstract: Repetitive DNA sequences are abundant in genomes and can adopt alternative DNA structures (i.e., non-B DNA). One such structure, Z-DNA, has been shown to stimulate genetic instability in a variety of organisms, including human cells… read more here.
Keywords: cancer; dna induced; genetic instability; effects aging ... See more keywords
Genetic Instability among Hitnü People Living in Colombian Crude-Oil Exploitation Areas
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph191811189
Abstract: Oil exploitation, drilling, transportation, and processing in refineries produces a complex mixture of chemical compounds, including polycyclic aromatic hydrocarbons (PAHs), which may affect the health of populations living in the zone of influence of mining… read more here.
Keywords: among hitn; oil; oil exploitation; genetic instability ... See more keywords