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Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23048
Abstract: Obesity, defined as a state of positive energy balance with a body mass index exceeding 30 kg/m2 in adults and 95th percentile in children, is an increasing global concern. Approximately one‐third of the world's population…
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Keywords:
genetic instability;
metabolic changes;
cancer;
obesity ... See more keywords
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Published in 2021 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2021.03.003
Abstract: Autosomal hereditary recessive diseases characterized by genetic instability are often associated with cancer predisposition. Bloom syndrome (BS), a rare genetic disorder, with
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Keywords:
genetic instability;
syndrome underlying;
bloom syndrome;
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Published in 2017 at "Carcinogenesis"
DOI: 10.1093/carcin/bgw116
Abstract: DNA mismatch repair (MMR) is integral to the maintenance of genetic stability. We aimed to evaluate the clinical impact of MMR gene expression in prostate cancer. The MMR genes MSH6, MLH1 and PMS2 were analyzed…
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Keywords:
genetic instability;
prostate cancer;
expression;
cancer ... See more keywords
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Published in 2022 at "Science"
DOI: 10.1126/science.ade4734
Abstract: Description Synchronized activation of DNA replication origins induces genetic instability in lymphoma Chromosomal translocations are promoted by DNA double-strand breaks (DSBs) that are joined inappropriately. They are common in cancer cells, and some are characteristic…
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Keywords:
translocation;
replication;
replication timing;
myc ... See more keywords
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Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2017.00236
Abstract: Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are…
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Keywords:
genetic instability;
risk factors;
breast cancer;
cancer ... See more keywords
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Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.926984
Abstract: Genome instability is a hallmark of cancer, and the function of lncRNAs in regulating genomic stability has been gradually characterized. However, the prognostic value of lncRNAs related to genetic instability has not been found in…
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Keywords:
instability;
breast cancer;
genetic instability;
instability related ... See more keywords
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Published in 2019 at "Genes"
DOI: 10.3390/genes10010040
Abstract: The near complete replacement of somatic chromatin in spermatids is, perhaps, the most striking nuclear event known to the eukaryotic domain. The process is far from being fully understood, but research has nevertheless unraveled its…
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Keywords:
genetic instability;
dna;
remodeling spermatids;
chromatin ... See more keywords
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Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph191811189
Abstract: Oil exploitation, drilling, transportation, and processing in refineries produces a complex mixture of chemical compounds, including polycyclic aromatic hydrocarbons (PAHs), which may affect the health of populations living in the zone of influence of mining…
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Keywords:
among hitn;
oil;
oil exploitation;
genetic instability ... See more keywords