Regulation of Notch signaling in the developing Drosophila eye by a T‐box containing transcription factor, Dorsocross
Sign Up to like & getrecommendations! Published in 2018 at "genesis"
DOI: 10.1002/dvg.23251
Abstract: Owing to a multitude of functions, there is barely a tissue or a cellular process that is not being regulated by Notch signaling. To allow the Notch signal to be deployed in numerous contexts, many… read more here.
Keywords: notch; eye discs; genetic interaction; notch signaling ... See more keywords
Design, execution, and analysis of CRISPR–Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans
Sign Up to like & getrecommendations! Published in 2019 at "Nature Protocols"
DOI: 10.1038/s41596-018-0122-6
Abstract: The study of fungal pathogens is of immediate importance, yet progress is hindered by the technical challenges of genetic manipulation. For Candida species, their inability to maintain plasmids, unusual codon usage, and inefficient homologous recombination… read more here.
Keywords: cas9 based; crispr cas9; candida; candida albicans ... See more keywords
Systematic analysis of Ca2+ homeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-04-0216
Abstract: The global landscape of Ca2+ homeostasis in budding yeast is deciphered. Quantified morphological responses under high concentration of Ca2+ and obtained high-dimensional Ca2+-genetic interaction profiles show functional gene clusters, which are used to build a… read more here.
Keywords: homeostasis; ca2 homeostasis; interaction profiles; genetic interaction ... See more keywords
A framework for exhaustive modelling of genetic interaction patterns using Petri nets
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz917
Abstract: MOTIVATION Genetic interaction (GI) patterns are characterized by the phenotypes of interacting single and double mutated gene pairs. Uncovering the regulatory mechanisms of GIs would provide a better understanding of their role in biological processes,… read more here.
Keywords: framework exhaustive; modelling; genetic interaction; patterns using ... See more keywords
Testing the Ret and Sema3d genetic interaction in mouse enteric nervous system development
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx084
Abstract: &NA; For most multigenic disorders, clinical manifestation (penetrance) and presentation (expressivity) are likely to be an outcome of genetic interaction between multiple susceptibility genes. Here, using gene knockouts in mice, we evaluated genetic interaction between… read more here.
Keywords: myenteric plexus; genetic interaction; ret sema3d; interaction ... See more keywords
Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx432
Abstract: Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin… read more here.
Keywords: systematic genetic; huntington disease; disease; pathology ... See more keywords
Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab680
Abstract: Abstract Gene deletion and gene expression alteration can lead to growth defects that are amplified or reduced when a second mutation is present in the same cells. We performed 154 genetic interaction mapping (GIM) screens… read more here.
Keywords: large scale; rna metabolism; gene; genetic interaction ... See more keywords
Higher-order epistasis and phenotypic prediction
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2020.10.14.339804
Abstract: Contemporary high-throughput mutagenesis experiments are providing an increasingly detailed view of the complex patterns of genetic interaction that occur between multiple mutations within a single protein or regulatory element. By simultaneously measuring the effects of… read more here.
Keywords: order epistasis; higher order; genetic interaction; phenotypic ... See more keywords
Genetic interaction with temperature is an important determinant of nematode longevity
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12658
Abstract: As in other poikilotherms, longevity in C. elegans varies inversely with temperature; worms are longer‐lived at lower temperatures. While this observation may seem intuitive based on thermodynamics, the molecular and genetic basis for this phenomenon… read more here.
Keywords: important determinant; interaction temperature; longevity; temperature ... See more keywords
SHP2's gain‐of‐function in Werner syndrome causes childhood disease onset likely resulting from negative genetic interaction
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14140
Abstract: Prompt diagnosis of complex phenotypes is a challenging task in clinical genetics. Whole exome sequencing has proved to be effective in solving such conditions. Here, we report on an unpredictable presentation of Werner Syndrome (WRNS)… read more here.
Keywords: interaction; likely resulting; negative genetic; resulting negative ... See more keywords
Genetic Interaction Analysis Reveals that Cryptococcus neoformans Utilizes Multiple Acetyl-CoA-Generating Pathways during Infection
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.01279-22
Abstract: The adaptation of environmental fungal pathogens to the mammalian host is critical to pathogenesis. Of these adaptations, the remodeling of carbon metabolism is particularly important. ABSTRACT Cryptococcus neoformans is an important human fungal pathogen for… read more here.
Keywords: acs1 kbc1; metabolism; acetyl coa; infection ... See more keywords