Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast
Sign Up to like & getrecommendations! Published in 2017 at "Nature genetics"
DOI: 10.1038/ng.3800
Abstract: Experiments in model organisms report abundant genetic interactions underlying biologically important traits, whereas quantitative genetics theory predicts, and data support, the notion that most genetic variance in populations is additive. Here we describe networks of… read more here.
Keywords: accounting genetic; genetics; quantitative trait; genetic interactions ... See more keywords
Behçet’s disease and genetic interactions between HLA-B*51 and variants in genes of autoinflammatory syndromes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-39113-5
Abstract: Behçet’s disease (BD) is an immune-mediated systemic disorder with a well-established genetic base. In a previous study, using a next generation sequencing approach, we found many rare variants and some functional polymorphisms in genes related… read more here.
Keywords: disease genetic; autoinflammatory syndromes; nod2 arg702trp; beh disease ... See more keywords
Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models
Sign Up to like & getrecommendations! Published in 2021 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddab012
Abstract: Abstract Down syndrome (DS) is the most common genetic form of intellectual disability caused by the presence of an additional copy of human chromosome 21 (Hsa21). To provide novel insights into genotype–phenotype correlations, we used… read more here.
Keywords: mouse models; multi influential; genetic interactions; biological cascades ... See more keywords
An Algorithm to Mine Therapeutic Motifs for Cancer From Networks of Genetic Interactions
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2022.3141076
Abstract: Study of pairwise genetic interactions, such as mutually exclusive mutations, has led to understanding of underlying mechanisms in cancer. Investigation of various combinatorial motifs within networks of such interactions can lead to deeper insights into… read more here.
Keywords: algorithm mine; genetic interactions; mine therapeutic; cancer ... See more keywords
Systematic analysis of complex genetic interactions
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aao1729
Abstract: Trigenic interactions in yeast link bioprocesses To dissect the genotype-phenotype landscape of a cell, it is necessary to understand interactions between genes. Building on the digenic protein-protein interaction network, Kuzmin et al. created a trigenic… read more here.
Keywords: digenic interaction; interaction network; genetic interactions; interaction ... See more keywords
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aax4438
Abstract: Manifold destiny Mapping of genetic interactions (GIs) is usually based on cell fitness as the phenotypic readout, which obscures the mechanistic origin of interactions. Norman et al. developed a framework for mapping and understanding GIs.… read more here.
Keywords: single cell; cell rna; exploring genetic; genetic interactions ... See more keywords
Synthetic Genetic Interactions Reveal a Dense and Cryptic Regulatory Network of Small Noncoding RNAs in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.01225-22
Abstract: sRNAs have long been purported to be a critical mechanism by which bacteria respond to stress; however, uncovering growth phenotypes for sRNA deletion strains in E. coli and related bacteria has proven particularly challenging. In… read more here.
Keywords: growth; deletion; deletion strains; srna deletion ... See more keywords
The Causes and Consequences of Genetic Interactions (Epistasis).
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of genomics and human genetics"
DOI: 10.1146/annurev-genom-083118-014857
Abstract: The same mutation can have different effects in different individuals. One important reason for this is that the outcome of a mutation can depend on the genetic context in which it occurs. This dependency is… read more here.
Keywords: interactions epistasis; genetics; consequences genetic; genetic interactions ... See more keywords
Mapping genetic interactions in cancer: a road to rational combination therapies
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0680-4
Abstract: The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated… read more here.
Keywords: mapping genetic; combination therapies; rational combination; genetic interactions ... See more keywords
Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006532
Abstract: Chemical-genetic interactions–observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes–contain rich functional information linking compounds to their cellular modes of action. To systematically identify these interactions, an array of mutants is… read more here.
Keywords: chemical compounds; genetic interaction; chemical genetic; genetic interactions ... See more keywords
Investigating Mitonuclear Genetic Interactions Through Machine Learning: A Case Study on Cold Adaptation Genes in Human Populations From Different European Climate Regions
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.575968
Abstract: Cold climates represent one of the major environmental challenges that anatomically modern humans faced during their dispersal out of Africa. The related adaptive traits have been achieved by modulation of thermogenesis and thermoregulation processes where… read more here.
Keywords: human populations; machine learning; mitonuclear genetic; genetic interactions ... See more keywords