Risk for Mood, Anxiety, and Psychotic Disorders in Individuals at High and Low Genetic Liability for Bipolar Disorder and Major Depression.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.2873
Abstract: Importance The nature of the genetic relationship between major depression and bipolar disorder remains unclear and might be clarified by considering disorders outside of the mood spectrum. Objective To better understand the relationship between genetic… read more here.
Keywords: genetic liability; high genetic; risk; anxiety ... See more keywords
Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of autism and developmental disorders"
DOI: 10.1007/s10803-022-05459-5
Abstract: Autism spectrum disorder (ASD), a heritable neurodevelopmental disorder, confers genetic liability that is often expressed among relatives through subclinical, genetically-meaningful traits, or endophenotypes. For instance, relative to controls, parents of individuals with ASD differ in… read more here.
Keywords: genetic liability; performance; autism; childhood ... See more keywords
Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological medicine"
DOI: 10.1017/s0033291722003646
Abstract: BACKGROUND Little is known about environmental factors that may influence associations between genetic liability to suicidality and suicidal behavior. METHODS This study examined whether a suicidality polygenic risk score (PRS) derived from a large genome-wide… read more here.
Keywords: suicide attempt; suicidality; genetic liability; trauma ... See more keywords
Genetic liability to schizophrenia is negatively associated with educational attainment in UK Biobank
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0328-6
Abstract: Schizophrenia is associated with impairments in several domains of cognitive function performance and reduced educational achievement [1]. Genetic liability conferred by common risk alleles can be directly estimated in individuals regardless of their affected status… read more here.
Keywords: schizophrenia; genetic liability; educational attainment; liability schizophrenia ... See more keywords
Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-01517-7
Abstract: Attention Deficit-Hyperactivity Disorder (ADHD) is a complex psychiatric and neurodevelopmental disorder that develops during childhood and spans into adulthood. ADHD’s aetiology is complex, and evidence about its cause and risk factors is limited. We leveraged… read more here.
Keywords: complex traits; risk; genetic liability; higher risk ... See more keywords
Association Between Childhood Green Space, Genetic Liability, and the Incidence of Schizophrenia.
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia bulletin"
DOI: 10.1093/schbul/sbaa058
Abstract: Childhood exposure to green space has previously been associated with lower risk of developing schizophrenia later in life. It is unclear whether this association is mediated by genetic liability or whether the 2 risk factors… read more here.
Keywords: risk; schizophrenia; genetic liability; green space ... See more keywords
Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population.
Sign Up to like & getrecommendations! Published in 2021 at "Schizophrenia bulletin"
DOI: 10.1093/schbul/sbaa193
Abstract: Genetic liability for schizophrenia is associated with psychopathology in early life. It is not clear if these associations are time dependent during childhood, nor if they are specific across different forms of psychopathology. Using genotype… read more here.
Keywords: schizophrenia; genetic liability; liability schizophrenia; childhood ... See more keywords
Genetic support of a causal relationship between cannabis use and educational attainment: a two-sample Mendelian randomization study of European ancestry.
Sign Up to like & getrecommendations! Published in 2022 at "Addiction"
DOI: 10.1111/add.16090
Abstract: BACKGROUND AND AIMS Excessive cannabis use may lead to lower educational attainment. However, this association may be due to confounders and reverse causality. We tested the potential causal relationship between cannabis use disorder (CUD) or… read more here.
Keywords: attainment; genetic liability; educational attainment; cannabis use ... See more keywords
Abstract 2281: The interrelationship between maternal periconception folate nutritional intake and child’s genetic liability in the etiology of childhood acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2281
Abstract: Maternal prenatal folate intake is associated with a decreased risk of acute lymphoblastic leukemia (ALL) in children. Genome-wide association studies (GWAS) show that variations in genes regulating folate metabolism impact serum folate level irrespective of… read more here.
Keywords: etiology; intake; folate intake; genetic liability ... See more keywords
Prematurity and genetic liability for autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2025 at "Genome Medicine"
DOI: 10.1186/s13073-025-01552-3
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by diverse presentations and a strong genetic component. Environmental factors, such as prematurity, have also been linked to increased liability for ASD, though the interaction between… read more here.
Keywords: preterm birth; preterm; asd; genetic liability ... See more keywords
Links between looking and speaking in autism and first-degree relatives: insights into the expression of genetic liability to autism
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Autism"
DOI: 10.1186/s13229-018-0233-5
Abstract: BackgroundRapid automatized naming (RAN; naming of familiar items presented in an array) is a task that taps fundamental neurocognitive processes that are affected in a number of complex psychiatric conditions. Deficits in RAN have been… read more here.
Keywords: degree relatives; genetic liability; first degree; autism ... See more keywords