Demographic History, Genetic Load, and the Efficacy of Selection in the Globally Invasive Mosquito Aedes aegypti
Sign Up to like & getrecommendations! Published in 2025 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaf066
Abstract: Abstract Aedes aegypti is the main vector species of yellow fever, dengue, Zika, and chikungunya. The species is originally from Africa but has experienced a spectacular expansion in its geographic range to a large swath… read more here.
Keywords: efficacy selection; history; demographic history; genetic load ... See more keywords
Genetic load has potential in large populations but is realized in small inbred populations
Sign Up to like & getrecommendations! Published in 2021 at "Evolutionary Applications"
DOI: 10.1111/eva.13216
Abstract: Populations with higher genetic diversity and larger effective sizes have greater evolutionary capacity (i.e., adaptive potential) to respond to ecological stressors. We are interested in how the variation captured in protein‐coding genes fluctuates relative to… read more here.
Keywords: diversity; deleterious mutations; populations realized; load ... See more keywords
Genetic load and viability of a future restored northern white rhino population
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DOI: 10.1111/eva.13683
Abstract: As biodiversity loss outpaces recovery, conservationists are increasingly turning to novel tools for preventing extinction, including cloning and in vitro gametogenesis of biobanked cells. However, restoration of populations can be hindered by low genetic diversity… read more here.
Keywords: northern white; load; genetic load; population ... See more keywords
Evolutionary rate and genetic load in an emblematic Mediterranean tree following an ancient and prolonged population collapse
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Ecology"
DOI: 10.1111/mec.15684
Abstract: Severe bottlenecks significantly diminish the amount of genetic diversity and the speed at which it accumulates (i.e., evolutionary rate). They further compromise the efficiency of natural selection to eliminate deleterious variants, which may reach fixation… read more here.
Keywords: diversity; evolutionary rate; load; population ... See more keywords
From high masked to high realized genetic load in inbred Scandinavian wolves
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DOI: 10.1111/mec.16802
Abstract: When new mutations arise at functional sites they are more likely to impair than improve fitness. If not removed by purifying selection, such deleterious mutations will generate a genetic load that can have negative fitness… read more here.
Keywords: genetic load; deleterious mutations; inbred scandinavian; high masked ... See more keywords
Genomes of Galápagos Mockingbirds Reveal the Impact of Island Size and Past Demography on Inbreeding and Genetic Load in Contemporary Populations
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DOI: 10.1111/mec.17665
Abstract: Restricted range size brings about noteworthy genetic consequences that may affect the viability of a population and eventually its extinction. Particularly, the question if an increase in inbreeding can avert the accumulation of genetic load… read more here.
Keywords: demography; island size; load; genetic load ... See more keywords
Abstract 514: Genetic load in cancer cell populations
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DOI: 10.1158/1538-7445.am2017-514
Abstract: Populations accumulate deleterious mutations that have yet to be removed by natural selection. This mutated portion of the population that does not contribute to its fitness is called the genetic load and is proportional to… read more here.
Keywords: cell; rate; cancer; growth ... See more keywords