Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low‐avoidance) and resistance (Roman high‐avoidance) to stress‐induced depression
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Behavior"
DOI: 10.1002/brb3.861
Abstract: The selective breeding of Roman High‐ (RHA) and Low‐Avoidance (RLA) rats for, respectively, rapid versus poor acquisition of the active avoidance response has generated two distinct phenotypes differing in many behavioral traits, including coping strategies… read more here.
Keywords: low avoidance; genetic model; depression; model vulnerability ... See more keywords
An efficient integrative resampling method for gene–trait association analysis
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22271
Abstract: Genetic association studies are popular for identifying genetic variants, such as single nucleotide polymorphisms (SNPs), that are associated with complex traits. Statistical tests are commonly performed one SNP at a time with an assumed mode… read more here.
Keywords: genetic model; analysis; association; model ... See more keywords
Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4659-2
Abstract: Aims/hypothesisIn a recent study using a standard additive genetic model, we identified a TBC1D4 loss-of-function variant with a large recessive impact on risk of type 2 diabetes in Greenlanders. The aim of the current study… read more here.
Keywords: type; type diabetes; risk variants; genetic model ... See more keywords
Feature, genetic model and distribution of calcareous insulating layers in marine strata of western Pearl River Mouth basin in north of South China Sea
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Central South University"
DOI: 10.1007/s11771-020-4553-1
Abstract: We have systematically investigated the feature, genetic model and distribution of calcareous insulating layers in marine strata of the I oil group in member 2 of Zhujiang formation (ZJ2I oil formation), western Pearl River Mouth… read more here.
Keywords: genetic model; feature genetic; model distribution; calcareous insulating ... See more keywords
Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2020.107208
Abstract: Alterations in habituation, a highly conserved form of non-associative learning, are suspected to contribute to a range of the complex behavioural phenotypes present in multiple neurodevelopmental disorders. While progress has been made in understanding the… read more here.
Keywords: genetic model; habituation; model organisms; throughput genetic ... See more keywords
Association of Kir6.2 gene rs5219 variation with type 2 diabetes: A meta-analysis of 21,464 individuals.
Sign Up to like & getrecommendations! Published in 2018 at "Primary care diabetes"
DOI: 10.1016/j.pcd.2018.03.004
Abstract: AIMS rs5219 is in Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) E23K gene, located at 11p15.1. Researches on the association between rs5219 gene polymorphism with type 2 diabetes mellitus (T2DM) were performed extensively, but… read more here.
Keywords: genetic model; analysis; association; type diabetes ... See more keywords
A zebrafish genetic model enables an invaluable discovery: a lifesaving treatment for a lymphatic anomaly
Sign Up to like & getrecommendations! Published in 2019 at "Lab Animal"
DOI: 10.1038/s41684-019-0401-z
Abstract: In medical research, treatments are often thought of as moving “from bench to bedside.” A new study identifies a specific treatment in zebrafish and brings it to a patient, highlighting the role of these animal… read more here.
Keywords: genetic model; invaluable discovery; zebrafish genetic; treatment ... See more keywords
A genetic model for in vivo proximity labelling of the mammalian secretome
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220149
Abstract: Organ functions are highly specialized and interdependent. Secreted factors regulate organ development and mediate homeostasis through serum trafficking and inter-organ communication. Enzyme-catalyzed proximity labeling enables the identification of proteins within a specific cellular compartment. Here,… read more here.
Keywords: genetic model; vivo proximity; proximity labelling; proximity ... See more keywords
Increased relapse to cocaine‐seeking in a genetic model for depression
Sign Up to like & getrecommendations! Published in 2019 at "Addiction Biology"
DOI: 10.1111/adb.12756
Abstract: The greatest difficulty in treating cocaine addiction is the enormous rates of relapse, which occur despite immense negative consequences. Relapse risks are even greater in addicts with comorbid depression, perhaps because they use drugs to… read more here.
Keywords: depression; genetic model; cocaine seeking; relapse ... See more keywords
The Burmese cat as a genetic model of type 2 diabetes in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Animal genetics"
DOI: 10.1111/age.12799
Abstract: The recent extension of genetic tools to the domestic cat, together with the serendipitous consequences of selective breeding, have been essential to the study of the genetic diseases that affect them. Cats are increasingly presented… read more here.
Keywords: diabetes humans; genetic model; model type; type diabetes ... See more keywords
Drosophila sechellia: A Genetic Model for Behavioral Evolution and Neuroecology.
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of genetics"
DOI: 10.1146/annurev-genet-071719-020719
Abstract: Defining the mechanisms by which animals adapt to their ecological niche is an important problem bridging evolution, genetics, and neurobiology. We review the establishment of a powerful genetic model for comparative behavioral analysis and neuroecology,… read more here.
Keywords: genetic model; evolution; behavioral evolution; genetics ... See more keywords