Genetic Obesity and Bariatric Surgery Outcome in 1014 Patients with Morbid Obesity
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DOI: 10.1007/s11695-019-04184-w
Abstract: Background Mutations in the leptin-melanocortin pathway genes are known to cause monogenic obesity. The prevalence of these gene mutations and their effect on weight loss response after bariatric surgery are still largely unknown. Objective To… read more here.
Keywords: surgery; bariatric surgery; genetic obesity; 1014 patients ... See more keywords
Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders
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DOI: 10.1007/s11892-020-01327-7
Abstract: The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown… read more here.
Keywords: syndromic obesity; bariatric surgery; obesity disorders; genetic obesity ... See more keywords
Genetic obesity: next-generation sequencing results of 1230 patients with obesity
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2018-105315
Abstract: Background Obesity is a global and severe health problem. Due to genetic heterogeneity, the identification of genetic defects in patients with obesity can be time consuming and costly. Therefore, we developed a custom diagnostic targeted… read more here.
Keywords: patients obesity; 1230 patients; genetic obesity; obesity ... See more keywords
Genetic obesity in children: overview of possible diagnoses with a focus on SH2B1 deletion.
Sign Up to like & getrecommendations! Published in 2021 at "Hormone research in paediatrics"
DOI: 10.1159/000520402
Abstract: INTRODUCTION Genetic obesity is rare, and quite challenging for pediatricians in terms of early identification. SH2B1 is an important component in the leptin-melanocortin pathway and is found to play an important role in leptin and… read more here.
Keywords: sh2b1 gene; insulin; genetic obesity; obesity ... See more keywords
Identifying underlying medical causes of pediatric obesity: Results of a systematic diagnostic approach in a pediatric obesity center
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DOI: 10.1371/journal.pone.0232990
Abstract: Background Underlying medical causes of obesity (endocrine disorders, genetic obesity disorders, cerebral or medication-induced obesities) are thought to be rare. Even in specialized pediatric endocrinology clinics, low diagnostic yield is reported, but evidence is limited.… read more here.
Keywords: underlying medical; systematic diagnostic; medical causes; genetic obesity ... See more keywords
[A clinical challenge of evaluation and management in children with genetic obesity].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]"
DOI: 10.3760/cma.j.cn112150-20220520-00508
Abstract: Obesity is a growing global public health problem, while 40%-70% of obesity is determined by genetic factors. This article focuses on the classification, disease characteristics, diagnosis and progressive treatment of childhood genetic obesity. The prevention… read more here.
Keywords: genetic obesity; clinical challenge; evaluation management; obesity ... See more keywords
Genetic Obesity-Causes and Treatments.
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric annals"
DOI: 10.3928/19382359-20230102-05
Abstract: Genetic abnormalities are responsible for up to 70% of severe, early onset obesity. With recent advances in genetic testing, more individuals with genetic etiology of excessive weight are being identified. However, treatment will need to… read more here.
Keywords: genetic obesity; obesity causes; etiology; causes treatments ... See more keywords