Genetic overlap between type 1 diabetes and other autoimmune diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in immunopathology"
DOI: 10.1007/s00281-021-00885-6
Abstract: Type 1 diabetes (T1D) is a chronic disease caused by the destruction of pancreatic β cells, which is driven by autoreactive T lymphocytes. It has been described that a high proportion of T1D patients develop… read more here.
Keywords: t1d; genetic overlap; autoimmune diseases; type diabetes ... See more keywords
Genes Within The Context of Development: Changes In Genetic Trait Architectures During Childhood and Adolescence
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.071
Abstract: Abstract The extent to which genetic aetiologies are shared between traits and disorders naturally depends on the genetic composition of the two phenotypes. While psychiatric disorders are diagnostic entities, defined by diagnostic criteria including the… read more here.
Keywords: genetic trait; genetic overlap; social communication; development ... See more keywords
Investigation of the genetic overlap between rheumatoid arthritis and psoriatic arthritis in a Greek population
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Rheumatology"
DOI: 10.1080/03009742.2016.1199734
Abstract: Objectives: Several rheumatoid arthritis (RA) susceptibility loci have also been found to be associated with psoriatic arthritis (PsA), demonstrating that there is a degree of genetic overlap between various autoimmune diseases. We sought to investigate… read more here.
Keywords: greek population; psa; genetic overlap; rheumatoid arthritis ... See more keywords
Genetic overlap between cortical brain morphometry and frontotemporal dementia risk.
Sign Up to like & getrecommendations! Published in 2023 at "Cerebral cortex"
DOI: 10.1093/cercor/bhad049
Abstract: Frontotemporal dementia (FTD) has a complex genetic etiology, where the precise mechanisms underlying the selective vulnerability of brain regions remain unknown. We leveraged summary-based data from genome-wide association studies (GWAS) and performed LD score regression… read more here.
Keywords: cortical brain; etiology; brain; risk ... See more keywords
Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Human reproduction"
DOI: 10.1093/humrep/deab254
Abstract: STUDY QUESTION Is there a shared genetic or causal association of endometriosis with asthma or what biological mechanisms may underlie their potential relationships? SUMMARY ANSWER Our results confirm a significant but non-causal association of endometriosis… read more here.
Keywords: endometriosis; asthma; gwas; analysis ... See more keywords
Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample
Sign Up to like & getrecommendations! Published in 2019 at "Psychosomatic Medicine"
DOI: 10.1097/psy.0000000000000771
Abstract: ABSTRACT Objective Results from twin studies examining the genetic overlap between type 2 diabetes and depression are currently inconclusive. This question has not been addressed in non-Western populations. We aimed to examine whether there are… read more here.
Keywords: type diabetes; overlap type; genetic overlap; diabetes depression ... See more keywords
Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders
Sign Up to like & getrecommendations! Published in 2024 at "Psychiatry and Clinical Neurosciences"
DOI: 10.1111/pcn.13742
Abstract: Anxiety disorders are prevalent and anxiety symptoms (ANX) co‐occur with many psychiatric disorders. We aimed to identify genomic loci associated with ANX, characterize its genetic architecture, and genetic overlap with psychiatric disorders. read more here.
Keywords: overlap psychiatric; genetic overlap; genomic loci; anxiety symptoms ... See more keywords
Potential bias in genetic correlations
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.ade8002
Abstract: Description Mating patterns across two traits can inflate estimates of genetic overlap Genome-wide association studies (GWASs) identify genetic variants associated with a trait. Most traits are associated with thousands of variants, and many variants are… read more here.
Keywords: bias genetic; biology; genetic correlations; genetic overlap ... See more keywords
Investigating the shared genetic basis of inflammatory bowel disease and systemic lupus erythematosus using genetic overlap analysis
Sign Up to like & getrecommendations! Published in 2024 at "BMC Genomics"
DOI: 10.1186/s12864-024-10787-0
Abstract: Inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE) are autoimmune diseases that often coexist clinically. This phenomenon might be due to shared genetic components. Genome-wide association study (GWAS) data for IBD and SLE were… read more here.
Keywords: bowel disease; analysis; inflammatory bowel; genetic overlap ... See more keywords
The genetic overlap between osteoporosis and craniosynostosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1020821
Abstract: Osteoporosis is the most prevalent bone condition in the ageing population. This systemic disease is characterized by microarchitectural deterioration of bone, leading to increased fracture risk. In the past 15 years, genome-wide association studies (GWAS),… read more here.
Keywords: craniosynostosis; osteoporosis craniosynostosis; osteoporosis; overlap osteoporosis ... See more keywords
Investigating Genetic Overlap between Alzheimer’s Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25168814
Abstract: There is evidence to support a link between abnormal lipid metabolism and Alzheimer’s disease (AD) risk. Similarly, observational studies suggest a comorbid relationship between AD and coronary artery disease (CAD). However, the intricate biological mechanisms… read more here.
Keywords: coronary artery; disease; genetic overlap; analysis ... See more keywords