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   Articles with "genetic perturbation" as a keyword



GPSAdb: a comprehensive web resource for interactive exploration of genetic perturbation RNA-seq datasets

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1066

Abstract: Abstract Gene knock-out/down methods are commonly used to explore the functions of genes of interest, but a database that systematically collects perturbed data is not available currently. Manual curation of all the available human cell… read more here.

Keywords: seq datasets; rna seq; gpsadb; genetic perturbation ... See more keywords

PertOrg 1.0: a comprehensive resource of multilevel alterations induced in model organisms by in vivo genetic perturbation

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac872

Abstract: Abstract Genetically modified organisms (GMOs) can be generated to model human genetic disease or plant disease resistance, and they have contributed to the exploration and understanding of gene function, physiology, disease onset and drug target… read more here.

Keywords: multilevel alterations; model organisms; pertorg; genetic perturbation ... See more keywords

PerturbAtlas: a comprehensive atlas of public genetic perturbation bulk RNA-seq datasets

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae851

Abstract: Manipulating gene expression is crucial for understanding gene function, with high-throughput sequencing techniques such as RNA-seq elucidating the downstream mechanisms involved. However, the lack of a standardized metadata format for small-scale perturbation expression datasets in… read more here.

Keywords: perturbatlas comprehensive; rna seq; perturbation; gene ... See more keywords

Genetic Perturbation Modelling for Human Cell Therapy With BRNET.

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recommendations! Published in 2025 at "IEEE journal of biomedical and health informatics"

DOI: 10.1109/jbhi.2025.3629554

Abstract: Cellular responses to genetic perturbations are prevalent in wide contexts from the fundamental understandings on pathology to the development of clinical therapies and the discovery of novel drug targets. Nonetheless, the substantial amount of possible… read more here.

Keywords: brnet; perturbation modelling; human cell; modelling human ... See more keywords

Genetic Perturbation of the Starch Biosynthesis in Maize Endosperm Reveals Sugar-Responsive Gene Networks

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2021.800326

Abstract: In maize, starch mutants have facilitated characterization of key genes involved in endosperm starch biosynthesis such as large subunit of AGPase Shrunken2 (Sh2) and isoamylase type DBE Sugary1 (Su1). While many starch biosynthesis enzymes have… read more here.

Keywords: perturbation starch; starch; genetic perturbation; starch biosynthesis ... See more keywords