A polycistronic transgene design for combinatorial genetic perturbations from a single transcript in Drosophila.
Sign Up to like & getrecommendations! Published in 2023 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1010792
Abstract: Experimental models that capture the genetic complexity of human disease and allow mechanistic explorations of the underlying cell, tissue, and organ interactions are crucial to furthering our understanding of disease biology. Such models require combinatorial… read more here.
Keywords: genetic perturbations; disease; drosophila; design ... See more keywords
Layers of Cryptic Genetic Variation Underlie a Yeast Complex Trait
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.301907
Abstract: To better understand cryptic genetic variation, Lee et al. comprehensively map the genetic basis of a trait that is typically suppressed in a yeast cross. By determining how three different genetic perturbations give rise... Cryptic… read more here.
Keywords: trait; genetic perturbations; layers cryptic; cryptic genetic ... See more keywords