Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abk2252
Abstract: The proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We… read more here.
Keywords: overexpression; proteasome; genetic pharmacologic; pathology ... See more keywords
Evaluating the Risks and Benefits of Genetic and Pharmacologic Interventions for Down Syndrome: Views of Parents.
Sign Up to like & getrecommendations! Published in 2020 at "American journal on intellectual and developmental disabilities"
DOI: 10.1352/1944-7558-125.1.1
Abstract: Researchers are investigating new technologies to mitigate or prevent symptoms of Down syndrome (DS), including chromosome silencing and pharmacotherapy. We surveyed parents of individuals with DS to assess their opinions on two hypothetical scenarios describing… read more here.
Keywords: pharmacologic interventions; evaluating risks; benefits genetic; risks benefits ... See more keywords
Genetic or pharmacologic inhibition of EGFR ameliorates sepsis-induced AKI
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21244
Abstract: Despite recent studies have demonstrated that the EGF receptor (EGFR) activation provided a renoprotective role during ischemic and folic acid-induced AKI, the role and regulation mechanism of EGFR in septic AKI remains unclear. Here, gefitinib,… read more here.
Keywords: egfr; genetic pharmacologic; induced aki; pharmacologic inhibition ... See more keywords