In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-017-2404-2
Abstract: PurposeThe purpose of the study is to investigate the enzyme(s) responsible for siponimod metabolism and to predict the inhibitory effects of fluconazole as well as the impact of cytochrome P450 (CYP) 2C9 genetic polymorphism on… read more here.
Keywords: metabolism; genetic polymorphism; siponimod metabolism; cyp2c9 ... See more keywords
Genetic polymorphism of Y-chromosomal STRs in Gujjar population of Punjab
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DOI: 10.1007/s00414-019-02227-6
Abstract: Y-STR polymorphism of Gujjar population was determined by using AmpFISTR®YfilerTM PCR amplification kit. A total 176 haplotypes were obtained after the analysis of 17 Y-STR loci in 176 genetically unrelated individuals. Haplotype diversity and discrimination… read more here.
Keywords: polymorphism chromosomal; chromosomal strs; gujjar population; genetic polymorphism ... See more keywords
Estimating genetic polymorphism in Bhuiyan population of eastern India using 20 autosomal STR loci
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DOI: 10.1007/s00414-020-02391-0
Abstract: We conducted a study of 182 unrelated adult individuals belonging to Bhuiyan population resident of Eastern India in order to estimate genetic polymorphism by using 20 autosomal STR loci. The results obtained from this study… read more here.
Keywords: bhuiyan population; eastern india; str loci; genetic polymorphism ... See more keywords
Association of the OAS3 rs1859330 G/A genetic polymorphism with severity of enterovirus-71 infection in Chinese Han children
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DOI: 10.1007/s00705-017-3381-6
Abstract: The 2’5’-oligoadenylate synthetase (OAS) is an interferon (IFN)-induced protein that plays an important role in the antiviral action of IFN, with OAS3 being one of the four OAS classes (OAS1, OAS2, OAS3, OASL). The effect… read more here.
Keywords: infection; rs1859330 genetic; oas3 rs1859330; severity ... See more keywords
The influence of milk protein genetic polymorphism on the physical properties of cultured milk
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DOI: 10.1016/j.idairyj.2017.11.009
Abstract: Abstract The effect of milk protein genetic polymorphism on the properties of cultured milk was studied, focussing on the rheological properties, the degree of syneresis, particle size distribution and fermentation metabolites. Significant effects of genetic… read more here.
Keywords: milk; protein genetic; protein; cultured milk ... See more keywords
Genetic Polymorphism and Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Periapical Lesions: Systematic Review.
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DOI: 10.1016/j.joen.2019.10.011
Abstract: INTRODUCTION Recent studies involving genetic polymorphism and expression have provided information about their role in periapical lesions. This study aimed to evaluate if there is an association between the genetic polymorphism and gene and protein… read more here.
Keywords: periapical lesions; systematic review; polymorphism expression; genetic polymorphism ... See more keywords
Genetic polymorphism and structure of wild and zoo populations of the fosa (Eupleridae, Carnivora), the largest living carnivoran of Madagascar
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DOI: 10.1016/j.mambio.2018.04.007
Abstract: Cryptoprocta ferox, or fosa, is the largest living endemic carnivoran of Madagascar, with presumably high dispersal capacity, and for which no broad scale phylogeographic study has been conducted to date. This species is considered “Vulnerable”… read more here.
Keywords: polymorphism; largest living; structure; genetic polymorphism ... See more keywords
Genetic polymorphism of vir genes of Plasmodium vivax in Myanmar.
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DOI: 10.1016/j.parint.2020.102233
Abstract: The Plasmodium vivax variant proteins encoded by vir genes are highly polymorphic antigens and are considered as one of key proteins of P. vivax for host immune evasion via antigenic variations. Because genetic diversity of… read more here.
Keywords: vir; polymorphism vir; vir genes; plasmodium vivax ... See more keywords
Effect of Genetic Polymorphism on the Response to PDE5 Inhibitors in Patients With Erectile Dysfunction: A Systematic Review and a Critical Appraisal.
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DOI: 10.1016/j.sxmr.2020.05.005
Abstract: INTRODUCTION Several treatment strategies are nowadays available for erectile dysfunction (ED) patients. Currently, oral phosphodiesterase type 5 inhibitors (PDE5Is) are the first-line therapy for ED. However, they are effective in all treated cases with variable… read more here.
Keywords: response; polymorphism response; erectile dysfunction; genetic polymorphism ... See more keywords
Genetic polymorphism of 27 Y-STR loci in Kazakh populations from Northern Kazakhstan
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DOI: 10.1080/03014460.2022.2039292
Abstract: Abstract Background Previous studies of the genetic polymorphism of the Y-chromosome of Kazakhs were focussed on the Eastern, Central, Southern, and Western regions of Kazakhstan. In addition, many of these studies were limited to 17… read more here.
Keywords: genetic polymorphism; str loci; population; kazakh ... See more keywords
Association between Q192R PON1 genetic polymorphism and major adverse cardiovascular events in patients treated with clopidogrel: an updated meta-analysis.
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DOI: 10.1080/14740338.2023.2212152
Abstract: BACKGROUND Clopidogrel's responsiveness may be affected by the paraoxonase-1 (PON1) enzyme encoded by the Q192R PON1 genetic variant. We aimed to determine the aggregated risk of MACEs associated with carrying Q192R PON1 genetic variant in… read more here.
Keywords: events patients; genetic polymorphism; patients treated; q192r pon1 ... See more keywords