Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.12259
Abstract: This case-control study assesses the association of a genetic risk score based on variants in a DNA repair pathway with risk of a second primary contralateral breast cancer after radiation therapy for a first breast… read more here.
Keywords: risk; contralateral breast; risk score; breast cancer ... See more keywords
Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.5491
Abstract: Key Points Question At what age do individuals with higher genetic risk of Alzheimer disease first show cognitive differences from individuals with lower genetic risk, and which of 32 cognitive measures show the earliest difference?… read more here.
Keywords: alzheimer; alzheimer disease; higher genetic; genetic risk ... See more keywords
Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2023.0706
Abstract: Importance Central serous chorioretinopathy (CSC) is a serous maculopathy of unknown etiology. Two of 3 previously reported CSC genetic risk loci are also associated with AMD. Improved understanding of CSC genetics may broaden our understanding… read more here.
Keywords: csc; loci; serous chorioretinopathy; risk ... See more keywords
Genetic Risk of Alzheimer's Disease and Sleep Duration in Non‐Demented Elders
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25910
Abstract: Growing evidence has suggested an association between sleep duration and Alzheimer's disease (AD), but it is unclear if sleep duration is a manifestation of the AD disease process. We studied whether genetic liability for AD… read more here.
Keywords: genetic risk; alzheimer disease; duration; sleep duration ... See more keywords
Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26416
Abstract: The aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual‐level genetic data available. read more here.
Keywords: resilience modulates; parkinson disease; polygenic resilience; genetic risk ... See more keywords
Systematic evaluation of cancer‐specific genetic risk score for 11 types of cancer in The Cancer Genome Atlas and Electronic Medical Records and Genomics cohorts
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2143
Abstract: Genetic risk score (GRS) is an odds ratio (OR)‐weighted and population‐standardized method for measuring cumulative effect of multiple risk‐associated single nucleotide polymorphisms (SNPs). We hypothesize that GRS is a valid tool for risk assessment of… read more here.
Keywords: risk; risk score; systematic evaluation; cancer ... See more keywords
Genetics, its role in preventing the pandemic of coronary artery disease
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cardiology"
DOI: 10.1002/clc.23627
Abstract: Epidemiologists have claimed for decades that about 50% of predisposition for coronary artery disease (CAD) is genetic. Advances in technology made possible the discovery of hundreds of genetic risk variants predisposing to CAD. Multiple clinical… read more here.
Keywords: risk; genetics; coronary artery; primary prevention ... See more keywords
The effect of weight on labor market outcomes: An application of genetic instrumental variables
Sign Up to like & getrecommendations! Published in 2019 at "Health Economics"
DOI: 10.1002/hec.3828
Abstract: Abstract This paper contributes to the literature on the labor market consequences of obesity by using a novel instrument: genetic risk score, which reflects the predisposition to higher body mass index (BMI) across many genetic… read more here.
Keywords: risk score; risk; genetic risk; labor market ... See more keywords
Saturated fatty acid intake, genetic risk and colorectal cancer incidence: A large-scale prospective cohort study.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of cancer"
DOI: 10.1002/ijc.34544
Abstract: Previous investigations mainly focused on the associations of dietary fatty acids with colorectal cancer (CRC) risk, which ignored gene-environment interaction and mechanisms interpretation. We conducted a case-control study (751 cases and 3058 controls) and a… read more here.
Keywords: sfa intake; crc; risk; fatty acid ... See more keywords
Sex‐specific characterization and evaluation of the Alzheimer's disease genetic risk factor sorl1 in zebrafish during aging and in the adult brain following a 100 ppb embryonic lead exposure
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3372
Abstract: Developmental lead (Pb) exposure is suggested in laboratory studies to be a trigger for neurodegenerative diseases such as Alzheimer's disease (AD). Sortilin‐related receptor, L (DLR class) A repeats‐containing (SORL1) is a recently identified AD genetic… read more here.
Keywords: risk; exposure; sorl1; expression ... See more keywords
Analysis of family histories suggests shared genetic risk for chronic thromboembolic pulmonary hypertension and venous thromboembolism
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12170
Abstract: Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) and acute pulmonary embolism (PE) are related phenotypes, however, previous reports have suggested that genetic risk factors for CTEPH and PE differ. Here we report that a family history… read more here.
Keywords: pulmonary hypertension; shared genetic; thromboembolic pulmonary; risk ... See more keywords