Association of a Pathway-Specific Genetic Risk Score With Risk of Radiation-Associated Contralateral Breast Cancer
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.12259
Abstract: This case-control study assesses the association of a genetic risk score based on variants in a DNA repair pathway with risk of a second primary contralateral breast cancer after radiation therapy for a first breast… read more here.
Keywords: risk; contralateral breast; risk score; breast cancer ... See more keywords
Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.5491
Abstract: Key Points Question At what age do individuals with higher genetic risk of Alzheimer disease first show cognitive differences from individuals with lower genetic risk, and which of 32 cognitive measures show the earliest difference?… read more here.
Keywords: alzheimer; alzheimer disease; higher genetic; genetic risk ... See more keywords
Overlap of Genetic Loci for Central Serous Chorioretinopathy With Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2023.0706
Abstract: Importance Central serous chorioretinopathy (CSC) is a serous maculopathy of unknown etiology. Two of 3 previously reported CSC genetic risk loci are also associated with AMD. Improved understanding of CSC genetics may broaden our understanding… read more here.
Keywords: csc; loci; serous chorioretinopathy; risk ... See more keywords
Profiles of Genetic Risks for Psychotic Disorders.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2025.1289
Abstract: Importance The etiologic interrelationship of 4 rare/controversial psychotic disorders (delusional disorder [DD], acute psychoses [AP], psychosis not otherwise specified [PNOS], and schizoaffective disorder [SAD]) is poorly understood. Objective To assess levels of the family genetic… read more here.
Keywords: pnos sad; disorder; genetic risks; psychotic disorders ... See more keywords
Genetic Risk of Alzheimer's Disease and Sleep Duration in Non‐Demented Elders
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DOI: 10.1002/ana.25910
Abstract: Growing evidence has suggested an association between sleep duration and Alzheimer's disease (AD), but it is unclear if sleep duration is a manifestation of the AD disease process. We studied whether genetic liability for AD… read more here.
Keywords: genetic risk; alzheimer disease; duration; sleep duration ... See more keywords
Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26416
Abstract: The aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual‐level genetic data available. read more here.
Keywords: resilience modulates; parkinson disease; polygenic resilience; genetic risk ... See more keywords
Shared genetic risk between anorexia nervosa and cardiovascular disease events: Evidence from genome‐wide association studies
Sign Up to like & getrecommendations! Published in 2024 at "Brain and Behavior"
DOI: 10.1002/brb3.3294
Abstract: Cardiovascular complications occur in up to 80% of patients with anorexia nervosa (AN), yet the underlying mechanisms warrant further investigation. We assessed the genetic correlation (rg) between AN and cardiovascular disease (CVD) events to inform… read more here.
Keywords: cardiovascular disease; anorexia nervosa; shared genetic; genetic risk ... See more keywords
Systematic evaluation of cancer‐specific genetic risk score for 11 types of cancer in The Cancer Genome Atlas and Electronic Medical Records and Genomics cohorts
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DOI: 10.1002/cam4.2143
Abstract: Genetic risk score (GRS) is an odds ratio (OR)‐weighted and population‐standardized method for measuring cumulative effect of multiple risk‐associated single nucleotide polymorphisms (SNPs). We hypothesize that GRS is a valid tool for risk assessment of… read more here.
Keywords: risk; risk score; systematic evaluation; cancer ... See more keywords
Genetics, its role in preventing the pandemic of coronary artery disease
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DOI: 10.1002/clc.23627
Abstract: Epidemiologists have claimed for decades that about 50% of predisposition for coronary artery disease (CAD) is genetic. Advances in technology made possible the discovery of hundreds of genetic risk variants predisposing to CAD. Multiple clinical… read more here.
Keywords: risk; genetics; coronary artery; primary prevention ... See more keywords
Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease
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DOI: 10.1002/glia.24677
Abstract: Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants are associated with genes highly expressed in astrocytes. However, the contribution of genetic risk within astrocytes to cellular processes relevant to… read more here.
Keywords: risk resilience; alzheimer disease; risk; genetic risk ... See more keywords
The effect of weight on labor market outcomes: An application of genetic instrumental variables
Sign Up to like & getrecommendations! Published in 2019 at "Health Economics"
DOI: 10.1002/hec.3828
Abstract: Abstract This paper contributes to the literature on the labor market consequences of obesity by using a novel instrument: genetic risk score, which reflects the predisposition to higher body mass index (BMI) across many genetic… read more here.
Keywords: risk score; risk; genetic risk; labor market ... See more keywords