Host Genetic Signatures of Susceptibility to Fungal Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2018_113
Abstract: Our relative inability to predict the development of fungal disease and its clinical outcome raises fundamental questions about its actual pathogenesis. Several clinical risk factors are described to predispose to fungal disease, particularly in immunocompromised… read more here.
Keywords: fungal disease; host genetic; disease; genetic signatures ... See more keywords
Molecular Profiling and Significance of Circulating Tumor Cell Based Genetic Signatures.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55947-6_8
Abstract: Cancer kills by metastasizing beyond the primary site. Early detection, surgical intervention and other treatments have improved the survival rates of patients with cancer, however, once metastasis occurs, responses to conventional therapies become significantly less… read more here.
Keywords: tumor cells; genetic signatures; circulating tumor; cancer ... See more keywords
Genetic signatures of plant resistance genes with known function within and between species
Sign Up to like & getrecommendations! Published in 2018 at "Genetica"
DOI: 10.1007/s10709-018-0044-9
Abstract: Plant disease resistance (R) genes have undergone significant evolutionary divergence to cope with rapid changes in pathogens. These highly variable evolutionary patterns may have contributed to diversity in R gene protein families or structures. Here,… read more here.
Keywords: plant; within species; genetic signatures; evolutionary patterns ... See more keywords
Connectomic-genetic signatures in the cerebral small vessel disease
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2022.105671
Abstract: Small vessel disease (SVD) is a disorder that causes vascular lesions in the entire parenchyma of the human brain. At present, it is not well known how primary and secondary damage interact to give rise… read more here.
Keywords: vessel disease; connectomic genetic; genetic signatures; small vessel ... See more keywords
Tracking population genetic signatures of local extinction with herbarium specimens.
Sign Up to like & getrecommendations! Published in 2022 at "Annals of botany"
DOI: 10.1093/aob/mcac061
Abstract: BACKGROUND AND AIMS Habitat degradation and landscape fragmentation dramatically lower population sizes of rare plant species. Decreasing population sizes may, in turn, negatively affect genetic diversity and reproductive fitness which can ultimately lead to local… read more here.
Keywords: population genetic; local extinction; genetic signatures; herbarium ... See more keywords
Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abe0690
Abstract: Neuronal identities Neurons of the mouse spinal cord can be identified by any of several metrics, including what neurotransmitters they use, what cells they connect to, where they are located, and what neuroprogenitor gave rise… read more here.
Keywords: conserved genetic; classes local; genetic signatures; projection ... See more keywords
Common genetic signatures of Alzheimer's disease in Down Syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.27096.2
Abstract: Background: People with Down Syndrome (DS) are born with an extra copy of Chromosome (Chr) 21 and many of these individuals develop Alzheimer's Disease (AD) when they age. This is due at least in part… read more here.
Keywords: alzheimer disease; disease; genetic signatures; disease syndrome ... See more keywords
Genetic signatures for Helicobacter pylori strains of West African origin
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188804
Abstract: Helicobacter pylori is a genetically diverse bacterial species that colonizes the stomach in about half of the human population. Most persons colonized by H. pylori remain asymptomatic, but the presence of this organism is a… read more here.
Keywords: african origin; west african; pylori strains; genetic signatures ... See more keywords
Distinct Genetic Signatures of Cortical and Subcortical Regions Associated with Human Memory
Sign Up to like & getrecommendations! Published in 2019 at "eNeuro"
DOI: 10.1523/eneuro.0283-19.2019
Abstract: Despite the discovery of gene variants linked to memory performance, understanding the genetic basis of adult human memory remains a challenge. Here, we devised an unsupervised framework that relies on spatial correlations between human transcriptome… read more here.
Keywords: subcortical memory; memory; memory regions; genetic signatures ... See more keywords
Genetic Signatures of Evolutionary Rescue by a Selective Sweep
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303173
Abstract: Inferring selective sweeps from genetic data has been a breakthrough in population genetics. The most prominent examples come from populations suddenly exposed to extreme stressors, such as insecticides... One of the most useful models in… read more here.
Keywords: evolutionary rescue; selective sweep; genetics; genetic signatures ... See more keywords
Novel Genetic Signatures Associated With Sporadic Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.851496
Abstract: Amyotrophic Lateral Sclerosis (ALS) is a complex polygenetic neurodegenerative disorder. Establishing a diagnosis for ALS is a challenging and lengthy process. By the time a diagnosis is made, the lifespan prognosis is only about two… read more here.
Keywords: associated sporadic; genetic signatures; novel genetic; lateral sclerosis ... See more keywords