Clinical impact of minimal residual disease and genetic subtypes on the prognosis of childhood acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34606
Abstract: This study analyzed data from two consecutive protocols for children newly diagnosed with acute lymphoblastic leukemia (ALL) to determine the clinical impact of minimal/measurable residual disease (MRD) and recently identified tumor genetic subtypes. read more here.
Keywords: residual disease; genetic subtypes; impact minimal; lymphoblastic leukemia ... See more keywords
Identification of genetic subtypes in follicular lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Blood Cancer Journal"
DOI: 10.1038/s41408-024-01111-w
Abstract: Follicular lymphoma (FL) exhibits considerable variability in biological features and clinical trajectories across patients. To dissect the diversity of FL, we utilized a Bernoulli mixture model to identify genetic subtypes in 713 pre-treatment tumor tissue… read more here.
Keywords: genetic subtypes; history; follicular lymphoma; subtypes follicular ... See more keywords
Proposal and validation of a method to classify genetic subtypes of diffuse large B cell lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80376-0
Abstract: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease whose prognosis is associated with clinical features, cell-of-origin and genetic aberrations. Recent integrative, multi-omic analyses had led to identifying overlapping genetic DLBCL subtypes. We used targeted… read more here.
Keywords: method classify; genetic subtypes; large cell; diffuse large ... See more keywords
Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018024729
Abstract: CH may be associated with broader ill health (worse performance status, increased and potentially novel comorbidities). Serum interleukin-6 is elevated in people with CH and genetic subtypes, providing a view of the human systemic inflammatory… read more here.
Keywords: clonal hematopoiesis; comorbid inflammatory; genetic subtypes; characteristics genetic ... See more keywords
Distinct features of three clinical subtypes in 533 patients with primary hypertrophic osteoarthropathy
Sign Up to like & getrecommendations! Published in 2025 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-025-03722-3
Abstract: Primary hypertrophic osteoarthropathy (PHO) is a rare genetic disorder classified into clinical subtypes and genetic subtypes. Previous clinical studies have primarily focused on case reports and family analyses, largely characterizing the genetic subtypes. However, there… read more here.
Keywords: primary hypertrophic; genetic subtypes; three clinical; hypertrophic osteoarthropathy ... See more keywords
Genetic subtypes of prediabetes, healthy lifestyle, and risk of type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2024 at "Diabetes"
DOI: 10.2337/db23-0699
Abstract: Prediabetes is a heterogenous metabolic state with various risk for development of type 2 diabetes (T2D). In this study, we used genetic data on 7,227 US Hispanic/Latinos without diabetes from the Hispanic Community Health Study/Study… read more here.
Keywords: genetic subtypes; healthy lifestyle; cluster; risk ... See more keywords
Telomere Maintenance Pathways in Lower-Grade Gliomas: Insights from Genetic Subtypes and Telomere Length Dynamics
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26094175
Abstract: Telomere maintenance mechanisms (TMMs) play a critical role in cancer biology, particularly in lower-grade gliomas (LGGs), where telomere dynamics and pathway activity remain poorly understood. In this study, we analyzed TCGA-LGG and CGGA datasets, focusing… read more here.
Keywords: genetic subtypes; lower grade; telomere maintenance; grade gliomas ... See more keywords