LAUSR

GENETIC TARGET VALIDATION FOR ATP-CITRATE LYASE INHIBITION

Sign Up to like & get
recommendations!
0 Published in 2017 at "Journal of the American College of Cardiology"

DOI: 10.1016/s0735-1097(17)35044-1

Abstract: Background: Bempedoic acid is a novel oral agent that reduces hepatic cholesterol synthesis by inhibiting ATP-citrate lyase (ACL) leading to upregulation of the LDL receptor and a reduction in plasma low-density lipoprotein cholesterol (LDL-C). Although… read more here.

Keywords: citrate lyase; atp citrate; target validation; genetic target ... See more keywords