Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24321
Abstract: Loci controlling DNA double‐strand breaks (DSBs) repair play an important role in defending against the harmful health effects of benzene, toluene, ethylbenzene, and xylene (BTEX), but their gene variants may alter their repair capacity. The… read more here.
Keywords: atm h2ax; h2ax loci; loci contribute; genetic variations ... See more keywords
Genetic variations of antioxidant genes and their association with male infertility in Vietnamese men
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24829
Abstract: Antioxidant genes, such as superoxide dismutase (SOD), catalase (CAT), and nitric oxide synthase (NOS), play critical roles in spermatogenesis and sperm functions. Polymorphisms of antioxidant genes have been shown to be strongly associated with sperm… read more here.
Keywords: association male; variations antioxidant; genes association; genetic variations ... See more keywords
Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27849
Abstract: Innate and acquired immunity responses are crucial for viral infection elimination. However, genetic variations in coding genes may exacerbate the inflammation or initiate devastating cytokine storms which poses severe respiratory conditions in coronavirus disease‐19 (COVID‐19).… read more here.
Keywords: toll like; cytokine receptors; cytokines cytokine; proinflammatory cytokines ... See more keywords
LncVar: Deciphering Genetic Variations Associated with Long Noncoding Genes.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8808-2_14
Abstract: Long noncoding RNAs (lncRNAs) are pervasively transcribed in various species and play important roles in many biological processes. The biological functions of most lncRNAs remain to be explored. Previous studies have revealed that a large… read more here.
Keywords: long noncoding; variations associated; associated long; genes lncvar ... See more keywords
Genetic variations of acidity in grape berries are controlled by the interplay between organic acids and potassium
Sign Up to like & getrecommendations! Published in 2020 at "Theoretical and Applied Genetics"
DOI: 10.1007/s00122-019-03524-9
Abstract: Key message In a grapevine segregating population, genomic regions governing berry pH were identified, paving the way for breeding new grapevine varieties best adapted to a warming climate. Abstract As a consequence of global warming,… read more here.
Keywords: potassium; tartaric acid; acidity; grapevine ... See more keywords
Role of resistin genetic variations in knee osteoarthritis pathogenesis, a cross sectional study
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04673-2
Abstract: Osteoarthritis (OA) is a serious health concern globally and is recognized by degradation of articular cartilage, bone remodeling and synovial inflammation. Resistin is an adipokine that shown to be involved in inflammatory process associated with… read more here.
Keywords: variations knee; resistin; study; resistin genetic ... See more keywords
Genetic Variations and Haplotypic Diversity in the Myostatin Gene of New Zealand Cattle Breeds.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144400
Abstract: Myostatin (MSTN) is a circulating factor that is secreted by muscle cells, and that acts upon those cells to inhibit the proliferation of muscle fibres during pre-natal muscle growth. The Polymerase Chain Reaction (PCR) coupled… read more here.
Keywords: intron exon; myostatin; new zealand; gene ... See more keywords
Mitochondrial sirtuins genetic variations and gastric cancer risk: evidence from retrospective observational study.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145951
Abstract: AIMS The purpose of the present study was to analyze the role of selected polymorphisms of SIRT3 and SIRT5 in gastric carcinogenesis. METHODS For this study, 500 blood samples of GC patients and 500 blood… read more here.
Keywords: sirtuins genetic; risk; mitochondrial sirtuins; selected polymorphisms ... See more keywords
Association between Genetic Variations of Mitochondrial Isocitrate Dehydrogenase (IDH2) and Acute Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146497
Abstract: PURPOSE Mitochondrial isocitrate dehydrogenase (IDH2) is a major contributor to cellular redox control. The aim of this study was to preliminary link IDH2 genetic variations to redox imbalance, atherogenesis and risk of acute myocardial infarction… read more here.
Keywords: genetic variations; dehydrogenase idh2; mitochondrial isocitrate; idh2 ... See more keywords
Genetic variations in the p11/tPA/BDNF pathway are associated with post stroke depression.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2017.09.055
Abstract: BACKGROUND The effects of BDNF on post stroke depression (PSD) may be influenced by genetic variations in intracellular signal transduction pathways, such as the p11/tPA/BDNF pathway. In this study, we aimed to determine the association… read more here.
Keywords: bdnf pathway; tpa bdnf; p11 tpa; genetic variations ... See more keywords
Human genetics and its impact on cardiovascular disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiology"
DOI: 10.1016/j.jjcc.2021.09.005
Abstract: Cardiovascular disease (CVD) is a major cause of death worldwide. Given that CVD is a highly heritable trait, researchers have attempted to fully understand the genetic basis of CVD for a long time. The human… read more here.
Keywords: genetics; genetics impact; human genetics; cardiovascular disease ... See more keywords