Aluminum hydroxide adjuvant diverts the uptake and trafficking of genetically detoxified pertussis toxin to lysosomes in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Microbiology"
DOI: 10.1111/mmi.14900
Abstract: Aluminum salts have been successfully utilized as adjuvants to enhance the immunogenicity of vaccine antigens since the 1930s. However, the cellular mechanisms behind the immune adjuvanticity effect of these materials in antigen‐presenting cells are poorly… read more here.
Keywords: aluminum; pertussis toxin; uptake trafficking; genetically detoxified ... See more keywords