Hemoglobinopathies—genetically diverse, clinically complex, and globally relevant
Sign Up to like & getrecommendations! Published in 2018 at "memo - Magazine of European Medical Oncology"
DOI: 10.1007/s12254-018-0402-4
Abstract: SummaryHemoglobinopathies represent the most frequent monogenic disorders worldwide. Migration during recent years led to a profoundly increasing number of patients in countries where the indigenous population has not been affected. This short review will give an… read more here.
Keywords: diverse clinically; clinically complex; genetically diverse; complex globally ... See more keywords
Pheochromocytomas and Paragangliomas, Genetically Diverse and Minimalist, All at Once!
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.01.009
Abstract: Pheochromocytomas and paragangliomas are infrequent, genetically heterogeneous neuroendocrine tumors. In this issue of Cancer Cell, Fishbein et al. report novel driver genes, pathogenic mechanisms, and markers of malignancy. Notably, the new findings support the long-held view… read more here.
Keywords: paragangliomas genetically; diverse minimalist; genetically diverse; pheochromocytomas paragangliomas ... See more keywords
Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.04.046
Abstract: Structural variations (SVs) and gene copy number variations (gCNVs) have contributed to crop evolution, domestication, and improvement. Here, we assembled 31 high-quality genomes of genetically diverse rice accessions. Coupling with two existing assemblies, we developed… read more here.
Keywords: rice; diverse rice; genomic variations; pan genome ... See more keywords
Detection of a range of genetically diverse chlamydiae in Australian domesticated and wild ungulates.
Sign Up to like & getrecommendations! Published in 2019 at "Transboundary and emerging diseases"
DOI: 10.1111/tbed.13171
Abstract: Chlamydiae are globally widespread obligate intracellular bacteria, which several species are a well-recognized threat to human and animal health. In Australia, the most successful chlamydial species are the infamous koala pathogen C. pecorum, and C. psittaci, an… read more here.
Keywords: psittaci; chlamydiae; domesticated wild; genetically diverse ... See more keywords
Protease Inhibitors Purified from the Canola Meal Extracts of Two Genetically Diverse Genotypes Exhibit Antidiabetic and Antihypertension Properties
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26072078
Abstract: Valorization of vegetable oil waste residues is gaining importance due to their high protein and polyphenol contents. Protease inhibitors (PIs), proteins from these abundantly available waste residues, have recently gained importance in treating chronic diseases.… read more here.
Keywords: inhibitors purified; bln 3347; genetically diverse; protease inhibitors ... See more keywords
Coronaviruses Are Abundant and Genetically Diverse in West and Central African Bats, including Viruses Closely Related to Human Coronaviruses
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DOI: 10.3390/v15020337
Abstract: Bats are at the origin of human coronaviruses, either directly or via an intermediate host. We tested swabs from 4597 bats (897 from the Democratic Republic of Congo (DRC), 2191 from Cameroon and 1509 from… read more here.
Keywords: genetically diverse; coronaviruses abundant; human coronaviruses; diverse west ... See more keywords
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.74419
Abstract: The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the pathogen’s ability to adapt to the variable immune pressures exerted by the host. Understanding this interplay has proven difficult, largely because experimentally tractable… read more here.
Keywords: genetically diverse; tuberculosis; host; host pathogen ... See more keywords