An Oral Nanovaccine Secreted by Genetically Engineered and Ultrasound‐Responsive Bacteria for Colon Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202414994
Abstract: Colorectal cancers represent a major global morbidity and mortality burden, neccessitating improved treatment paradigms. In this work, an ingestible, genetically engineered Escherichia coli (E. coli) 1917 termed “E. coli (AH1‐CDA‐Co1)” is designed that upon ultrasound… read more here.
Keywords: coli ah1; ah1 cda; genetically engineered; tumor ... See more keywords
Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201583
Abstract: Conventional drug delivery systems are challenged by concerns related to systemic toxicity, repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery systems are developed to overcome these limitations. Nanomaterials are employed in a… read more here.
Keywords: delivery systems; organic based; drug delivery; drug ... See more keywords
A Genetically Engineered “Reinforced Concrete” Scaffold Regulates the N2 Neutrophil Innate Immune Cascade to Repair Bone Defects
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202304585
Abstract: The innate immune response is crucial to inflammation, but how neutrophils and macrophages act in bone repair and tissue engineering treatment strategies await clarification. In this study, it is found that N2 neutrophils release stronger… read more here.
Keywords: bone; genetically engineered; repair; innate immune ... See more keywords
Bioinspired Functionally Graded Composite Assembled Using Cellulose Nanocrystals and Genetically Engineered Proteins with Controlled Biomineralization.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202102658
Abstract: Nature provides unique insights into design strategies evolved by living organisms to construct robust materials with a combination of mechanical properties that are challenging to replicate synthetically. Hereby, inspired by the impact-resistant dactyl club of… read more here.
Keywords: genetically engineered; functionally graded; bioinspired functionally; graded composite ... See more keywords
Tumor Cell Nanovaccines Based on Genetically Engineered Antibody‐Anchored Membrane
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202208923
Abstract: Despite the promise in whole‐tumor cell vaccines, a key challenge is to overcome the lack of costimulatory signals. Here, agonistic‐antibody‐boosted tumor cell nanovaccines are reported by genetically engineered antibody‐anchored membrane (AAM) technology, capable of effectively… read more here.
Keywords: cell; anchored membrane; tumor cell; tumor ... See more keywords
Modular Design of T Cell Nanoengagers for Tumor Immunotherapy via Genetically Engineered Lipid‐Tagged Antibody Fragments
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202503060
Abstract: T cell engagers, which bind tumor‐associated antigens and T cell specific molecules, represent a promising class of immunotherapies for enhancing targeted immune responses. Here, a “plug‐and‐display” platform is introduced for engineering T cell nanoengagers by… read more here.
Keywords: antibody fragments; genetically engineered; cell; tumor ... See more keywords
Genetically Engineered Organization: Protein Template, Biological Recognition Sites, and Nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.201600285
Abstract: Nanoparticles and their assemblies exhibit properties that can be used for a wide range of applications. However, creating multifunctional assemblies has remained challenging. Inspired by magnetotactic bacteria, genetically engineered single building blocks from magnetosome chains… read more here.
Keywords: protein; engineered organization; genetically engineered; protein template ... See more keywords
Physiochemically and Genetically Engineered Bacteria: Instructive Design Principles and Diverse Applications
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202403156
Abstract: With the comprehensive understanding of microorganisms and the rapid advances of physiochemical engineering and bioengineering technologies, scientists are advancing rationally‐engineered bacteria as emerging drugs for treating various diseases in clinical disease management. Engineered bacteria specifically… read more here.
Keywords: design principles; engineered bacteria; genetically engineered; physiochemically genetically ... See more keywords
A Genetically Engineered Biomimetic Nanodecoy for the Treatment of Liver Fibrosis
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DOI: 10.1002/advs.202405026
Abstract: Liver fibrosis, arising from factors such as viral infections or metabolic disorders, represents an ongoing global health challenge and is a major risk factor for hepatocellular carcinoma. Unfortunately, there are no clinically approved drugs available… read more here.
Keywords: treatment; fibrosis; biomimetic nanodecoy; genetically engineered ... See more keywords
Genetically Engineered Bacteria as a Promising Therapeutic Strategy Against Cancer: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2738
Abstract: As a significant cause of global mortality, the cancer has also economic impacts. In the era of cancer therapy, mitigating side effects and costs and overcoming drug resistance is crucial. Microbial species can grow inside… read more here.
Keywords: cancer; engineered bacteria; bacteria promising; genetically engineered ... See more keywords
The regulatory landscape of genetically engineered crops in Pakistan
Sign Up to like & getrecommendations! Published in 2024 at "Food and Energy Security"
DOI: 10.1002/fes3.494
Abstract: Genome editing technology has become part and parcel of biotechnological approach to understand the genetic basis of different biological processes in an organism and for its application in different fields. The basic need of world… read more here.
Keywords: genome edited; genetically engineered; edited crops; act ... See more keywords