Genetically Predicted Brain C4A Expression Is Associated With TSPO and Hippocampal Morphology
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2021.06.021
Abstract: BACKGROUND Alterations in the immune system, particularly C4A, have been implicated in the pathophysiology of schizophrenia. C4A promotes synapse elimination by microglia in preclinical models; however, it is unknown whether this process is also present… read more here.
Keywords: c4a; c4a expression; brain c4a; genetically predicted ... See more keywords
Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobank
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.007
Abstract: Background High circulating low-density lipoprotein cholesterol (LDL-C) is a major risk factor for atherosclerosis and age-associated cardiovascular events. Long-term dyslipidaemia could contribute to the development of frailty in older individuals through its role in determining… read more here.
Keywords: mendelian randomization; density lipoprotein; lipoprotein cholesterol; low density ... See more keywords
Association of genetically-predicted lipid traits and lipid-modifying targets with heart failure.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of preventive cardiology"
DOI: 10.1093/eurjpc/zwac290
Abstract: AIMS To assess the association of genetically-predicted lipid traits and lipid-modification via licensed or investigational targets with heart failure (HF). METHODS AND RESULTS Two-sample Mendelian randomization (MR) study was conducted using summary-level genome-wide association studies… read more here.
Keywords: association genetically; traits lipid; genetically predicted; lipid traits ... See more keywords
M88. EVIDENCE FOR INFLAMMATION AS A PUTATIVE SHARED MECHANISM FOR INSULIN RESISTANCE AND SCHIZOPHRENIA
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa030.400
Abstract: Abstract Background Insulin Resistance (IR) predisposes to cardiometabolic disorders, which are common in schizophrenia and are associated with excess morbidity and mortality. The mechanisms of association remain unknown. We aimed 1) To use genetic data… read more here.
Keywords: insulin; schizophrenia; shared mechanism; inflammation ... See more keywords
Abstract 598: Genetically predicted concentration of circulating proteins and epithelial ovarian cancer risk
Sign Up to like & getrecommendations! Published in 2019 at "Epidemiology"
DOI: 10.1158/1538-7445.am2019-598
Abstract: Epithelial ovarian cancer (EOC) is the most common gynecological cancer, and ranks fifth in cancer deaths among women in the United States. Previous studies have identified several circulating proteins biomarkers for EOC risk, such as… read more here.
Keywords: genetically predicted; ovarian cancer; cancer; risk ... See more keywords
Abstract 3519: Genetically predicted plasma N-glycans and prostate cancer risk: Analysis of over 140,000 European descendants
Sign Up to like & getrecommendations! Published in 2020 at "Epidemiology"
DOI: 10.1158/1538-7445.am2020-3519
Abstract: Prostate cancer is the second most frequently diagnosed malignancy among males in many countries. There are critical needs to better understand its etiology and identifying effective biomarkers to improve its early detection. Many proteins are… read more here.
Keywords: glycans prostate; prostate cancer; cancer risk; genetically predicted ... See more keywords
Abstract 6504: Germline genetically predicted body mass index is associated with endometrial cancer somatic transcriptomic, immune, and mutational signatures in The Cancer Genome Atlas
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6504
Abstract: High body mass index (BMI) is a causal risk factor for endometrial cancer but the molecular mechanisms underlying this association remain elusive. Here we sought to characterize the tumor genomic landscape of endometrial cancers that… read more here.
Keywords: endometrial cancer; genetically predicted; pgs; bmi ... See more keywords
Abstract 16179: Concordance Between Machine Learning-based Methods of Atrial Fibrillation Subtyping in 49,905 Individuals and Relationship to Genetically Predicted Af Risk and Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.16179
Abstract: Introduction: Atrial Fibrillation (AF) is a heterogeneous arrythmia. Identification of subgroups of patients with shared mechanisms, such as genetic predisposition to AF and inflammation, could facilitate precision care. Machine learning (ML) is increasingly applied to… read more here.
Keywords: genetically predicted; atrial fibrillation; machine learning; inflammation ... See more keywords
The association of arterial stiffness index with cerebrovascular and cardiometabolic disease: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Stroke"
DOI: 10.1177/17474930211066432
Abstract: Background: Arterial stiffness index (ASI) is a potential risk factor for cerebrovascular and cardiometabolic diseases, but the causal links between them are inconclusive. The aim is to evaluate the causal effects of ASI on cerebrovascular… read more here.
Keywords: genetically predicted; cerebrovascular cardiometabolic; mendelian randomization; stiffness index ... See more keywords
Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1009078
Abstract: Telomeres are DNA-protein structures at the ends of chromosomes essential in maintaining chromosomal stability. Observational studies have identified associations between telomeres and elevated cancer risk, including hematologic malignancies; but biologic mechanisms relating telomere length to… read more here.
Keywords: telomere length; copy number; predicted telomere; genetically predicted ... See more keywords
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Medicine"
DOI: 10.1371/journal.pmed.1003706
Abstract: Background Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index (FMI), fat-free… read more here.
Keywords: risk; digestive system; site specific; specific cancers ... See more keywords