Genetically Predicted Gene Expression Effects on Changes in Red Blood Cell and Plasma Polyunsaturated Fatty Acids
Sign Up to like & getrecommendations! Published in 2025 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22613
Abstract: Polyunsaturated fatty acids (PUFAs) including omega‐3 and omega‐6 are obtained from diet and can be measured objectively in plasma or red blood cells (RBCs) membrane biomarkers, representing different dietary exposure windows. In vivo conversion of… read more here.
Keywords: gene expression; polyunsaturated fatty; blood; expression ... See more keywords
Genetically Predicted Brain C4A Expression Is Associated With TSPO and Hippocampal Morphology
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2021.06.021
Abstract: BACKGROUND Alterations in the immune system, particularly C4A, have been implicated in the pathophysiology of schizophrenia. C4A promotes synapse elimination by microglia in preclinical models; however, it is unknown whether this process is also present… read more here.
Keywords: c4a; c4a expression; brain c4a; genetically predicted ... See more keywords
Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobank
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.007
Abstract: Background High circulating low-density lipoprotein cholesterol (LDL-C) is a major risk factor for atherosclerosis and age-associated cardiovascular events. Long-term dyslipidaemia could contribute to the development of frailty in older individuals through its role in determining… read more here.
Keywords: mendelian randomization; density lipoprotein; lipoprotein cholesterol; low density ... See more keywords
Genetically predicted serum urate and cancer risk: A Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2025 at "Scandinavian journal of rheumatology"
DOI: 10.1080/03009742.2025.2512667
Abstract: Objective To evaluate the causal effect of genetically predicted serum urate (SU) levels on the risk of overall and major site-specific cancers in individuals of European ancestry, using Mendelian randomization (MR) analysis. Method Data from… read more here.
Keywords: cancer; study; risk; serum urate ... See more keywords
Causal associations between environmental factors and risk of IgA nephropathy and membranous nephropathy: a bidirectional Mendelian randomization and mediation analysis
Sign Up to like & getrecommendations! Published in 2025 at "Renal Failure"
DOI: 10.1080/0886022x.2025.2486620
Abstract: Abstract Aims IgA nephropathy (IgAN) and membranous nephropathy (MN) have intricate etiologies that are poorly understood. This study aimed to investigate the impact of genetically predicted environmental factors on IgAN and MN. Methods We used… read more here.
Keywords: environmental factors; membranous nephropathy; risk; iga nephropathy ... See more keywords
Association of genetically-predicted lipid traits and lipid-modifying targets with heart failure.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of preventive cardiology"
DOI: 10.1093/eurjpc/zwac290
Abstract: AIMS To assess the association of genetically-predicted lipid traits and lipid-modification via licensed or investigational targets with heart failure (HF). METHODS AND RESULTS Two-sample Mendelian randomization (MR) study was conducted using summary-level genome-wide association studies… read more here.
Keywords: association genetically; traits lipid; genetically predicted; lipid traits ... See more keywords
Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Epidemiology"
DOI: 10.1093/ije/dyae125
Abstract: Abstract Background Higher body mass index (BMI) is associated with higher incidence of cardiovascular and some non-cardiovascular diseases (CVDs/non-CVDs). However, uncertainty remains about its associations with mortality, particularly at lower BMI levels. Methods The prospective… read more here.
Keywords: predicted bmi; mortality; major vascular; bmi ... See more keywords
Genetically predicted effects of COVID-19 on 2272 traits: exploring through a phenome-wide Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2025 at "Postgraduate medical journal"
DOI: 10.1093/postmj/qgaf037
Abstract: BACKGROUND The COVID-19 pandemic has significantly impacted global health, making it essential to understand its genetic effects on various traits. METHOD Leveraging the extensive FinnGen dataset comprising 500 000 individuals, we performed a Mendelian randomization (MR)… read more here.
Keywords: effects covid; study; phenome wide; mendelian randomization ... See more keywords
M88. EVIDENCE FOR INFLAMMATION AS A PUTATIVE SHARED MECHANISM FOR INSULIN RESISTANCE AND SCHIZOPHRENIA
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa030.400
Abstract: Abstract Background Insulin Resistance (IR) predisposes to cardiometabolic disorders, which are common in schizophrenia and are associated with excess morbidity and mortality. The mechanisms of association remain unknown. We aimed 1) To use genetic data… read more here.
Keywords: insulin; schizophrenia; shared mechanism; inflammation ... See more keywords
Genetically Predicted Frailty Index Is Associated With Increased Risk of Multiple Metabolic Diseases: 175 226 European Participants in a Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.70062
Abstract: A relationship between frailty index (FI) and metabolic diseases (MDs) has been reported in previous observational studies. However, the causality between them remains unclear. This study aimed to examine the causal effect of FI on… read more here.
Keywords: genetically predicted; frailty index; metabolic diseases; study ... See more keywords
Genetically Predicted Plasma Metabolome Mediates the Causal Link Between Immune Cells and Risk of Gout
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.70094
Abstract: Gout is a prevalent metabolic disorder characterized by a multifaceted process of development. Recent research has emphasized a robust correlation between the immune response and gout. Nevertheless, it is still uncertain if this connection is… read more here.
Keywords: gout; immune cells; metabolome mediates; plasma metabolome ... See more keywords