Genie in a bottle: controlled release helps tame natural polypharmacology?
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DOI: 10.1016/j.cbpa.2019.02.014
Abstract: Ability to faithfully report drug-target interactions constitutes a major critical parameter in preclinical/clinical settings. Yet the assessment of target engagement remains challenging, particularly for promiscuous and/or polypharmacologic ligands. Drawing from our improved insights into native… read more here.
Keywords: helps tame; bottle controlled; controlled release; polypharmacology ... See more keywords