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   Articles with "genipin" as a keyword



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Design of a bactericidal hydrogel scaffold containing genipin crosslinked HF‐18 peptide

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recommendations! Published in 2022 at "Biotechnology Progress"

DOI: 10.1002/btpr.3314

Abstract: Wound healing is a process getting affected by internal and external factors and might be interrupted by infections. To overcome infections during wound healing, novel antibacterial agents such as antimicrobial peptides have gained popularity because… read more here.

Keywords: bactericidal hydrogel; design bactericidal; wound healing; genipin ... See more keywords

Monitoring implantable immunoisolation devices with intrinsic fluorescence of genipin.

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recommendations! Published in 2019 at "Journal of biophotonics"

DOI: 10.1002/jbio.201800170

Abstract: Imaging of implanted hydrogel-based biosystems usually requires indirect labeling of the vehicle or cargo, adding complexity and potential risk of altering functionality. Here, for the first time, it is reported that incorporation of genipin into… read more here.

Keywords: genipin; fluorescence; immunoisolation devices; implantable immunoisolation ... See more keywords
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Genipin induces cell death via intrinsic apoptosis pathways in human glioblastoma cells

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.27512

Abstract: Genipin, a compound derived from Gardenis jasminoides Ellis fruits, was demonstrated to be the specific uncoupling protein 2 (UCP2) inhibitor. UCP2 is a mitochondrial carrier protein that creates proton leaks across the inner mitochondrial membrane,… read more here.

Keywords: genipin; effect genipin; glioblastoma; apoptosis ... See more keywords
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Characterization and Optimization of Injectable in situ Crosslinked Chitosan-Genipin Hydrogels.

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recommendations! Published in 2023 at "Macromolecular bioscience"

DOI: 10.1002/mabi.202200505

Abstract: In recent years, there has been an increased interest in injectable, in situ crosslinking hydrogels due to their minimally invasive application and ability to conform to their environment. Current in situ crosslinking chitosan hydrogels are… read more here.

Keywords: genipin hydrogels; genipin; situ crosslinking; chitosan genipin ... See more keywords
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Genipin Inhibits LPS-Induced Inflammatory Response in BV2 Microglial Cells

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recommendations! Published in 2017 at "Neurochemical Research"

DOI: 10.1007/s11064-017-2289-6

Abstract: Genipin, an aglycon of geniposide, has been reported to have anti-inflammatory effect. However, the anti-inflammatory activity of genipin on LPS-stimulated BV2 microglial cells has not been reported. In this study, we investigated the molecular mechanisms… read more here.

Keywords: genipin; lps induced; bv2 microglial; inflammatory response ... See more keywords
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A hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier ocular drug delivery platform

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recommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ajps.2018.08.002

Abstract: The objective of this study was to develop a novel hybrid genipin-crosslinked dual-sensitive hydrogel/nanostructured lipid carrier (NLC) drug delivery platform. An ophthalmic anti-inflammatory drug, baicalin (BN) was chosen as the model drug. BN—NLC was prepared… read more here.

Keywords: sensitive hydrogel; genipin; hydrogel; drug delivery ... See more keywords
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Molecular Mechanisms Responsible for Pharmacological Effects of Genipin on Mitochondrial Proteins

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recommendations! Published in 2019 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2019.10.021

Abstract: Genipin, a natural compound from Gardenia jasminoides, is a well-known compound in Chinese medicine that is used for the treatment of cancer, inflammation, and diabetes. The use of genipin in classical medicine is hindered because… read more here.

Keywords: mitochondrial proteins; medicine; genipin; mechanisms responsible ... See more keywords
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Diffusion and relaxation contributions in the release of vitamin B6 from a moving boundary of genipin crosslinked gelatin matrices

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recommendations! Published in 2019 at "Food Hydrocolloids"

DOI: 10.1016/j.foodhyd.2018.09.015

Abstract: Abstract A fundamental study was carried out to evaluate patterns of vitamin B6 release from genipin crosslinked gelatin in aqueous media at ambient temperature. Up to ninety percent crosslinking was achieved, with FTIR and WAXD… read more here.

Keywords: relaxation contributions; diffusion relaxation; genipin crosslinked; crosslinked gelatin ... See more keywords
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Genipin inhibits allergic responses in ovalbumin‐induced asthmatic mice

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.10.010

Abstract: Abstract Genipin is a natural compound isolated from the fruit of Gardenia jasminoides with various pharmacological effects. In this study, we investigated whether genipin effectively alleviates allergic responses in a murine model of ovalbumin (OVA)‐induced… read more here.

Keywords: genipin; asthmatic mice; induced asthmatic; ova ... See more keywords
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Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury.

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recommendations! Published in 2019 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2019.105842

Abstract: The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT)… read more here.

Keywords: genipin; lps induced; apoptosis; pi3k akt ... See more keywords
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Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 β in neonatal rats.

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recommendations! Published in 2019 at "Nutrition"

DOI: 10.1016/j.nut.2018.05.017

Abstract: OBJECTIVES Bronchopulmonary dysplasia is the most common chronic lung disease of infancy and is associated with pulmonary hypertension (PH). Inhibition of glycogen synthase kinase (GSK)-3 β has been shown to attenuate lung injury and PH… read more here.

Keywords: genipin; lung injury; expression; factor ... See more keywords