Geniposide protects pancreatic β cells from high glucose‐mediated injury by activation of AMP‐activated protein kinase
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10758
Abstract: Our previous works indicated that geniposide could regulate glucose‐stimulated insulin secretion (GSIS), and improved chronic high glucose‐induced dysfunctions in pancreatic β cells, but the molecular mechanisms remain largely unknown. In the present study, we investigated… read more here.
Keywords: activated protein; high glucose; pancreatic cells; injury ... See more keywords
Geniposide inhibits glucolipotoxicity and cooperates with Txnip knockdown to potentiate cell adaption to endoplasmic reticulum stress in pancreatic beta cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11350
Abstract: Thioredoxin‐interacting protein (Txnip), a negative regulator of thioredoxin, has become an attractive therapeutic target to alleviate metabolic diseases. Our previous data demonstrated that geniposide improved glucose‐stimulated insulin secretion by accelerating Txnip degradation and prevented the… read more here.
Keywords: inhibits glucolipotoxicity; geniposide inhibits; pancreatic cells; cell ... See more keywords
Geniposide ameliorates chronic unpredictable mild stress induced depression-like behavior through inhibition of ceramide-PP2A signaling via the PI3K/Akt/GSK3β axis.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05895-8
Abstract: BACKGROUND Depression is a severe mental disorder. Unfortunately, more than half of patients with major depression disorder cannot achieve remission after initial treatment with an antidepressant. Geniposide, a bioactive iridoid glycoside isolated from Gardenia jasminoides… read more here.
Keywords: depression; geniposide; pi3k akt; ceramide ... See more keywords
Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106547
Abstract: The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in cerebral ischemia. Autophagy may cause microglial inflammatory response or stimulate microglial function. The evidences clarify a direct crosstalk between autophagy and NLRP3. Geniposide… read more here.
Keywords: autophagy; activation; oxygen glucose; nlrp3 inflammasome ... See more keywords
Detection of saffron adulteration with gardenia extracts through the determination of geniposide by liquid chromatography–mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Food Composition and Analysis"
DOI: 10.1016/j.jfca.2016.11.004
Abstract: Abstract A new and sophisticated saffron adulteration method with gardenia was recently discovered in the European saffron market. In this work, an analytical methodology using liquid chromatography-(quadrupole-time of flight)-mass spectrometry has been developed for the… read more here.
Keywords: methodology; mass spectrometry; saffron; adulteration ... See more keywords
CREB-mediated generation and neuronal growth regulates the behavioral improvement of geniposide in diabetes-associated depression mouse model
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Research"
DOI: 10.1016/j.neures.2020.05.003
Abstract: Metabolic disorder particularly diabetes is one of the leading causes of psychiatric or other neurodegenerative diseases. Previous clinical and pre-clinical studies indicate anti-diabetic drugs such as GLP-1 analogs or GLP-1 receptor (GLP-1R) agonists could perform… read more here.
Keywords: associated depression; creb; model; diabetes associated ... See more keywords
Geniposide Alleviates Oxidative Damage in Hepatocytes through Regulating miR-27b-3p/Nrf2 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03856
Abstract: Geniposide (GEN), a main compound extracted from Gardenia jasminoides fruit, has various biological activities including anti-inflammation, cellular damage alleviation, neuroprotection, and others. However, the effect of GEN on oxidative stress in hepatic cells is yet… read more here.
Keywords: oxidative damage; geniposide; gen; mir 27b ... See more keywords
Anti-inflammatory action of geniposide promotes wound healing in diabetic rats
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2030760
Abstract: Abstract Context As a major active iridoid glycoside from Gardenia jasminoides J. Ellis (Rubiaceae), geniposide possesses various pharmacological activities, including anti-platelet aggregation and anti-inflammatory action. Objectives This study explores the effect of geniposide in diabetic… read more here.
Keywords: inflammatory action; diabetic rats; wound healing; anti inflammatory ... See more keywords
Combined Administration of Vitamin D3 and Geniposide Is Less Effective than Single Use of Vitamin D3 or Geniposide in the Treatment of Ulcerative Colitis
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DOI: 10.3389/fphar.2021.714065
Abstract: With the increasing incidence of ulcerative colitis (UC) in China, Chinese medicinal herbs or relatively active compounds are widely applied in treating UC. These medicines may be combined with other therapeutic agents such as vitamin… read more here.
Keywords: vitamin geniposide; colon; colitis; geniposide vitamin ... See more keywords
Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide
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DOI: 10.3390/molecules27103319
Abstract: At present, the potential of natural products in new drug development has attracted more and more scientists’ attention, and natural products have become an important source for the treatment of various diseases or important lead… read more here.
Keywords: effect; potential natural; geniposide; natural product ... See more keywords