Antiamyloid β toxicity effect of genistein via activation of DAF‐16 and HSP‐16.2 signal pathways in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23055
Abstract: β‐Amyloid toxicity (Aβ) is an important pathological factor of Alzheimer's disease (AD). Studies have shown that genistein can reduce the toxicity of Aβ to a certain extent; however, the specific mechanism is still uncertain. In… read more here.
Keywords: effect genistein; hsp; toxicity; caenorhabditis elegans ... See more keywords
Genistein-induced Anticancer Effects on Acute Leukemia Cells Involve the Regulation of Wnt Signaling Pathway Through H4K20me1 Rather Than DNA Demethylation
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-021-2445-8
Abstract: To investigate the effects and mechanisms of genistein on the gene expression in the Wnt pathway in acute leukemia (AL) cells. The expression of Wnt pathway genes and cell cycle-related genes were analyzed in two… read more here.
Keywords: genistein; leukemia cells; cell cycle; acute leukemia ... See more keywords
Involvement of SIRT1 in Amelioration of Schistosomiasis-Induced Hepatic Fibrosis by Genistein.
Sign Up to like & getrecommendations! Published in 2021 at "Acta tropica"
DOI: 10.1016/j.actatropica.2021.105961
Abstract: Previous study revealed that genistein alleviate the extent of hepatic fibrosis in schistosomiasis-infected mice, however, the potential mechanism is still incomplete. Present study was, therefore, carried out to investigate the underlying mechanism of ameliorating schistosomiasis-induced… read more here.
Keywords: fibrosis; genistein; expression; hepatic fibrosis ... See more keywords
Metformin in combination with genistein ameliorates skeletal muscle inflammation in high-fat diet fed c57BL/6 mice.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155638
Abstract: Although the beneficial effects of metformin (MET) and genistein in ameliorating inflammation have been elucidated, their combined impacts on skeletal muscle inflammation have not been clearly understood. This study aimed to examine the possible preventive… read more here.
Keywords: combination; skeletal muscle; genistein; inflammation ... See more keywords
Effects of nitro- and amino-group on the antioxidant activity of genistein: A theoretical study.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2018.09.108
Abstract: Five novel compounds (Gen-NO2, Gen-2NO2, Gen-NH2, Gen-2NH2 and Gen-6NH2) have been designed via introducing an electron-withdrawing group -NO2 and an electron-donating group -NH2 into the structure of genistein. The effects of -NO2 and -NH2 groups… read more here.
Keywords: antioxidant activity; genistein; chemistry; group ... See more keywords
Protective effect of genistein on the ischemic acute kidney injury in the rat.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144789
Abstract: BACKGROUND This study determined the possible anti-inflammatory and antioxidant renal protective effect of genistein, a soy isoflavone, against kidney damage and functional disorders following renal ischemia/reperfusion (I/R) in male rats. MATERIALS AND METHODS The animals… read more here.
Keywords: genistein; protective effect; effect genistein; sham ... See more keywords
Genistein modulates the estrogen receptor and suppresses angiogenesis and inflammation in the murine model of peritoneal endometriosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Traditional and Complementary Medicine"
DOI: 10.1016/j.jtcme.2017.03.002
Abstract: The purpose of this study was to investigate the effect of genistein administration on the modulation of the estrogen receptor, inhibition of inflammation and angiogenesis in the murine model of peritoneal endometriosis. A total of… read more here.
Keywords: endometriosis; genistein; group; receptor ... See more keywords
Individual factors define the overall effects of dietary genistein exposure on breast cancer patients.
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition research"
DOI: 10.1016/j.nutres.2019.03.015
Abstract: As an endocrine disruptor, tyrosine kinase inhibitor, and DNA methyltransferase inhibitor, genistein can interfere with breast cancer development. However, as the results of numerous studies are contradictory, it is unclear whether genistein plays a positive… read more here.
Keywords: genistein; individual factors; cancer; breast cancer ... See more keywords
Dietary genistein supplementation alters mRNA expression profile and alternative splicing signature in the thymus of chicks with lipopolysaccharide challenge.
Sign Up to like & getrecommendations! Published in 2021 at "Poultry science"
DOI: 10.1016/j.psj.2021.101561
Abstract: Genistein is abundant in the soybean products, which exerts prominent effects on immune function. Little information is available about the effect of dietary genistein on thymic transcriptome, especially when suffering from lipopolysaccharide challenge. In this… read more here.
Keywords: expression profile; genistein; dietary genistein; lipopolysaccharide challenge ... See more keywords
Genistein Protects against Acetaldehyde-Induced Oxidative Stress and Hepatocyte Injury in Chronic Alcohol-Fed Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05747
Abstract: Alcohol-related liver disease (ALD) is one of the most prevalent forms of liver disease in the world. Acetaldehyde, an intermediate product of alcohol catabolism, is a cause of liver injury caused by alcohol. This study… read more here.
Keywords: acetaldehyde induced; oxidative stress; alcohol; injury ... See more keywords
IRMPD Spectroscopy of Bare Monodeprotonated Genistein, an Antioxidant Flavonoid
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01236
Abstract: Genistein is a naturally occurring polyphenol belonging to the family of flavonoids with estrogenic properties and proven antioxidant, anti-inflammatory, and hormonal effects. Genistein and its derivatives are involved in radical scavenging activity by way of… read more here.
Keywords: spectroscopy; irmpd spectroscopy; spectroscopy bare; genistein ... See more keywords