Ovariectomized mice and postmenopausal women exhibit analogous loss of genital epithelial integrity.
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DOI: 10.1080/21688370.2020.1865760
Abstract: ABSTRACT Roughly half of all postmenopausal women are affected by the genitourinary syndrome of menopause (GSM). Symptoms of GSM, including vaginal irritation and dyspareunia, occur as reduced estrogen (E) production elicits loss of elasticity and… read more here.
Keywords: genital epithelial; epithelial integrity; mice; postmenopausal women ... See more keywords
Genital epithelial barrier function is conserved by intravaginal rings releasing etonogestrel and ethinyl estradiol.
Sign Up to like & getrecommendations! Published in 2023 at "Tissue barriers"
DOI: 10.1080/21688370.2023.2186672
Abstract: The injectable progestin depot-medroxyprogesterone acetate (DMPA) is a popular contraceptive choice in sub-Saharan Africa although mouse models indicate it weakens genital epithelial integrity and barrier function and increases susceptibility to genital infection. The intravaginal ring… read more here.
Keywords: barrier function; function; genital epithelial; ethinyl estradiol ... See more keywords