The emerging role of homologous recombination repair and PARP inhibitors in genitourinary malignancies
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30631
Abstract: As cells age and are exposed to genotoxic stress, preservation of the genomic code requires multiple DNA repair pathways to remove single‐strand or double‐strand breaks. Loss of function somatic genomic aberrations or germline deficiency in… read more here.
Keywords: parp inhibitors; genitourinary malignancies; homologous recombination; strand ... See more keywords
Single-Cell Sequencing in Genitourinary Malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-4494-1_13
Abstract: Single-cell sequencing (SCS) is a powerful new tool that applies Next Generation Sequencing at the cellular level. SCS has revolutionized our understanding of tumor heterogeneity and the tumor microenvironment, immune infiltration, cancer stem cells (CSCs),… read more here.
Keywords: single cell; genitourinary malignancies; heterogeneity; cell sequencing ... See more keywords
Targeting the Tumor Microenvironment with Immunotherapy for Genitourinary Malignancies
Sign Up to like & getrecommendations! Published in 2018 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-018-0523-3
Abstract: Opinion statementBacillus Calmette-Guérin in urothelial carcinoma, high-dose interleukin-2 in renal cell carcinoma, and sipuleucel-T in prostate cancer serve as enduring examples that the host immune response can be harnessed to promote effective anti-tumor immunity in… read more here.
Keywords: carcinoma; response; immunotherapy; genitourinary malignancies ... See more keywords
Using Imaging to Predict Treatment Response in Genitourinary Malignancies.
Sign Up to like & getrecommendations! Published in 2018 at "European urology focus"
DOI: 10.1016/j.euf.2017.09.003
Abstract: CONTEXT Over the previous2 decades, there have been numerous advancements in the diagnostic evaluation, therapeutic management, and postoperative assessment of genitourinary malignancies. OBJECTIVE To present a review of current and novel imaging modalities and their… read more here.
Keywords: treatment response; response; genitourinary malignancies; treatment ... See more keywords
The Role of PD-L1 Testing in Advanced Genitourinary Malignancies.
Sign Up to like & getrecommendations! Published in 2019 at "European urology focus"
DOI: 10.1016/j.euf.2019.03.003
Abstract: In accordance with US Food and Drug Administration recommendations, tumor PD-L1 expression should be assessed in all patients with platinum-ineligible metastatic urothelial carcinoma (mUC), and patients with low PD-L1 expression should not receive single-agent immune… read more here.
Keywords: advanced genitourinary; genitourinary malignancies; role testing; urology ... See more keywords
Suicide Risk Among Patients with Genitourinary Malignancies: Where Do We Stand?
Sign Up to like & getrecommendations! Published in 2019 at "European urology focus"
DOI: 10.1016/j.euf.2019.09.007
Abstract: Urologists should optimize personalized care for individuals with a mental health illness following diagnosis of a genitourinary malignancy, be mindful of psychiatric wellbeing, and involve mental health specialists at the earliest opportunity to improve primary… read more here.
Keywords: genitourinary malignancies; patients genitourinary; among patients; suicide risk ... See more keywords
Waning efficacy of COVID-19 vaccination at six months in patients (pts) with genitourinary malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2022.40.6_suppl.185
Abstract: 185 Background: Short-term effectiveness of COVID-19 vaccination is widely demonstrated, but the emerging real-world data suggest that immunity may wane over-time (Levin et al. NEJM 2021). Herein we aimed to explore the long-term efficacy of the… read more here.
Keywords: genitourinary malignancies; efficacy covid; vaccination; pts genitourinary ... See more keywords
Cabozantinib in genitourinary malignancies.
Sign Up to like & getrecommendations! Published in 2017 at "Future oncology"
DOI: 10.2217/fon-2016-0358
Abstract: Cabozantinib inhibits a variety of cellular receptors including VEGFR1-3, MET, AXL, RET, FLT3 and KIT. These signaling pathways have been shown to be important in genitourinary malignancies. Along its clinical development, it has shown most… read more here.
Keywords: oncology; carcinoma; cabozantinib genitourinary; genitourinary malignancies ... See more keywords
PET-CT in Clinical Adult Oncology—IV. Gynecologic and Genitourinary Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14123000
Abstract: Simple Summary Positron emission tomography (PET), typically combined with computed tomography (CT), has become a critical advanced imaging technique in oncology. With concurrently acquired positron emission tomography and computed tomography (PET-CT), a radioactive molecule (radiotracer)… read more here.
Keywords: oncology; genitourinary malignancies; adult; pet ... See more keywords