Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals
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DOI: 10.1021/acs.chemrestox.3c00318
Abstract: To modernize genotoxicity assessment and reduce reliance on experimental animals, new approach methodologies (NAMs) that provide human-relevant dose–response data are needed. Two transcriptomic biomarkers, GENOMARK and TGx-DDI, have shown a high classification accuracy for genotoxicity.… read more here.
Keywords: classification; transcriptomic biomarkers; genotoxicity assessment; genomark ... See more keywords