Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31040
Abstract: Y-box binding protein 1 (YBX1) is a member of the family of DNA- and RNA-binding proteins that play crucial roles in multiple aspects, including RNA stabilization, translational repression, and transcriptional regulation; however, its roles in… read more here.
Keywords: genome activation; binding protein; zygotic genome; box binding ... See more keywords
Altered expression of BRG1 and histone demethylases, and aberrant H3K4 methylation in less developmentally competent embryos at the time of embryonic genome activation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22762
Abstract: Epigenetics is a fundamental regulator underlying many biological functions, such as development and cell differentiation. Epigenetic modifications affect key chromatin regulation, including transcription and DNA repair, which are critical for normal embryo development. In this… read more here.
Keywords: embryonic genome; methylation; brg1; genome activation ... See more keywords
Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.05.037
Abstract: The awakening of the genome after fertilization is a cornerstone of animal development. However, the mechanisms that activate the silent genome after fertilization are poorly understood. Here, we show that transcriptional competency is regulated by… read more here.
Keywords: genome activation; brd4; transcriptional competency; p300 ... See more keywords
DNA methylation dynamics during zygotic genome activation in goat.
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2020.07.008
Abstract: DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic development. However, the subtle changes in DNA methylation differ in species, and, little information is known regarding the dynamics of DNA methylation… read more here.
Keywords: methylation; genome activation; zygotic genome; methylation dynamics ... See more keywords
Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell research"
DOI: 10.1038/s41422-022-00652-8
Abstract: Chromatin remodeling is essential for epigenome reprogramming after fertilization. However, the underlying mechanisms of chromatin remodeling remain to be explored. Here, we investigated the dynamic changes in nucleosome occupancy and positioning in pronucleus-stage zygotes using… read more here.
Keywords: genome; nucleosome positioning; fertilization; genome activation ... See more keywords
Mechanisms regulating zygotic genome activation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Genetics"
DOI: 10.1038/s41576-018-0087-x
Abstract: Following fertilization, the two specified gametes must unite to create an entirely new organism. The genome is initially transcriptionally quiescent, allowing the zygote to be reprogrammed into a totipotent state. Gradually, the genome is activated… read more here.
Keywords: transition; mechanisms regulating; genome activation; zygotic genome ... See more keywords
Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse†, ‡
Sign Up to like & getrecommendations! Published in 2018 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioy004
Abstract: Abstract Understanding factors that regulate zygotic genome activation (ZGA) is critical for determining how cells are reprogrammed to become totipotent or pluripotent. There is limited information regarding how this process occurs physiologically in early mammalian… read more here.
Keywords: genome activation; zygotic genome; med13; mediator complex ... See more keywords
USP16-mediated histone H2A lysine-119 deubiquitination during oocyte maturation is a prerequisite for zygotic genome activation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac468
Abstract: Abstract Maternal-to-zygotic transition (MZT) is the first and key step in the control of animal development and intimately related to changes in chromatin structure and histone modifications. H2AK119ub1, an important epigenetic modification in regulating chromatin… read more here.
Keywords: genome activation; genome; zygotic genome; oocyte maturation ... See more keywords
Germline/soma distinction in Drosophila embryos requires regulators of zygotic genome activation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.03.24.485643
Abstract: In Drosophila melanogaster embryos, somatic versus germline identity is the first cell fate decision. Zygotic genome activation (ZGA) orchestrates regionalized gene expression, imparting specific identity on somatic cells. ZGA begins with a minor wave that… read more here.
Keywords: genome activation; soma distinction; zygotic genome; germline ... See more keywords
A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn4935
Abstract: Transition from maternal to embryonic transcriptional control is crucial for embryogenesis. However, alternative splicing regulation during this process remains understudied. Using transcriptomic data from human, mouse, and cow preimplantation development, we show that the stage… read more here.
Keywords: damage; damage response; genome activation; zygotic genome ... See more keywords
CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf2687
Abstract: Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is known about the role of chromatin factors during this process. Here, we used an in vivo RNA interference reverse genetic… read more here.
Keywords: genome activation; gcn5; zygotic genome; zga ... See more keywords