Markov chains improve the significance computation of overlapping genome annotations
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac255
Abstract: Motivation Genome annotations are a common way to represent genomic features such as genes, regulatory elements or epigenetic modifications. The amount of overlap between two annotations is often used to ascertain if there is an… read more here.
Keywords: chains improve; genome annotations; significance; markov chains ... See more keywords
Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.230938.117
Abstract: Technological advances promise unprecedented opportunities for whole exome sequencing and proteomic analyses of populations. Currently, data from genome and exome sequencing or proteomic studies are searched against reference genome annotations. This provides the foundation for… read more here.
Keywords: research; recognition polycistronic; alternative orfs; genome annotations ... See more keywords