Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.001
Abstract: The TP53 tumor suppressor gene is frequently mutated in human cancers. An analysis of five data platforms in 10,225 patient samples from 32 cancers reported by The Cancer Genome Atlas (TCGA) enables comprehensive assessment of… read more here.
Keywords: cancer genome; genome atlas; expression; cancer ... See more keywords
Differential alternative RNA splicing and transcription events between tumors from African American and white patients in The Cancer Genome Atlas.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.02.020
Abstract: Individuals of African ancestry suffer disproportionally from higher incidence, aggressiveness, and mortality for particular cancers. This disparity likely results from an interplay among differences in multiple determinants of health, including differences in tumor biology. We… read more here.
Keywords: cancer genome; race; differential alternative; genome atlas ... See more keywords
Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology–molecular associations: clinical and biological implications
Sign Up to like & getrecommendations! Published in 2017 at "Modern Pathology"
DOI: 10.1038/modpathol.2016.198
Abstract: The Cancer Genome Atlas data on colorectal carcinoma have provided a comprehensive view of the tumor’s genomic alterations and their tumorigenic roles. Tumor morphology, however, has not been fully integrated into the analysis. The aim… read more here.
Keywords: cancer genome; genome atlas; morphology; colorectal cancers ... See more keywords
Exploring the Cancer Genome Atlas (TCGA) for the molecular profile of young onset colorectal cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.3548
Abstract: 3548Background: Colorectal cancer (CRC) incidence and mortality has been declining, in part due to increased implementation of screening, but the incidence among patients under 50 (young onset, YO)... read more here.
Keywords: cancer genome; genome atlas; young onset; exploring cancer ... See more keywords
Discovering drugs to overcome chemoresistance in ovarian cancers based on the cancer genome atlas tumor transcriptome profile
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22870
Abstract: Ovarian cancer accounts for the highest mortality among gynecologic cancers, mainly due to intrinsic or acquired chemoresistance. While mechanistic-based methods have been used to identify compounds that can overcome chemoresistance, an effective comprehensive drug screening… read more here.
Keywords: overcome chemoresistance; chemoresistance; cancer genome; genome atlas ... See more keywords
SGLT-2 as a potential target in pancreatic cancer: the preliminary clue from The Cancer Genome Atlas data
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-900
Abstract: Background Sodium-glucose co-transporters-2 (SGLT-2) has been reported as overexpressed in tumors including pancreatic cancer (PC). The aim of this study was to investigate the clinicopathological and prognostic significance, as well as the potential role of… read more here.
Keywords: genome atlas; pancreatic cancer; sglt; expression ... See more keywords
Exploring epigenetic biomarkers of universal specificities and commonalities among pan-cancer cohorts in The Cancer Genome Atlas.
Sign Up to like & getrecommendations! Published in 2021 at "Epigenomics"
DOI: 10.2217/epi-2021-0050
Abstract: Aim: To explore the mechanism of cancer by employing a comprehensive analysis of DNA methylation patterns and variations among pan-cancer cohorts. Materials & methods: This research focused on the discovery of universally specific or common biomarkers by mathematical… read more here.
Keywords: pan cancer; cancer genome; genome atlas; among pan ... See more keywords
Using The Cancer Genome Atlas as an Inquiry Tool in the Undergraduate Classroom
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.573992
Abstract: Undergraduate students in the biomedical sciences are often interested in future health-focused careers. This presents opportunities for instructors in genetics, molecular biology, and cancer biology to capture their attention using lab experiences built around clinically… read more here.
Keywords: cancer genome; genetics; genome atlas; using cancer ... See more keywords
DNTTIP1 is a Prognostic Biomarker Correlated With Immune Infiltrates in Hepatocellular Carcinoma: A Study Based on The Cancer Genome Atlas Data
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.767834
Abstract: Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) is involved in the deacetylation of p53 in regulating cell cycle and is associated with cancers at the molecular level. In this study, we evaluated the prognostic value in hepatocellular… read more here.
Keywords: genome atlas; hepatocellular carcinoma; study; cancer ... See more keywords
PR/SET Domain Family and Cancer: Novel Insights from The Cancer Genome Atlas
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19103250
Abstract: The PR/SET domain gene family (PRDM) encodes 19 different transcription factors that share a subtype of the SET domain [Su(var)3-9, enhancer-of-zeste and trithorax] known as the PRDF1-RIZ (PR) homology domain. This domain, with its potential… read more here.
Keywords: cancer genome; set domain; family; genome atlas ... See more keywords
Prognostic microRNAs and their potential molecular mechanism in pancreatic cancer: A study based on The Cancer Genome Atlas and bioinformatics investigation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.7945
Abstract: Although certain biomarkers that are directly associated with the overall survival (OS) of patients with pancreatic adenocarcinoma (PAAD) have been identified, the efficacy of a single factor is limited to predicting the prognosis. The aim… read more here.
Keywords: cancer genome; present study; study; genome atlas ... See more keywords