Genome-coverage single-cell histone modifications for embryo lineage tracing
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-025-08656-1
Abstract: Substantial epigenetic resetting during early embryo development from fertilization to blastocyst formation ensures zygotic genome activation and leads to progressive cellular heterogeneities1, 2–3. Mapping single-cell epigenomic profiles of core histone modifications that cover each individual… read more here.
Keywords: histone modifications; genome coverage; single cell; lineage ... See more keywords
Target enrichment improves culture-independent detection of Neisseria gonorrhoeae and antimicrobial resistance determinants direct from clinical samples with Nanopore sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Microbial Genomics"
DOI: 10.1099/mgen.0.001208
Abstract: Abstract Multi-drug-resistant Neisseria gonorrhoeae infection is a significant public health risk. Rapidly detecting N. gonorrhoeae and antimicrobial-resistant (AMR) determinants by metagenomic sequencing of urine is possible, although high levels of host DNA and overgrowth of… read more here.
Keywords: detection; genome coverage; coverage; culture ... See more keywords
Rapid viral metagenomics using SMART-9N amplification and nanopore sequencing
Sign Up to like & getrecommendations! Published in 2021 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.17170.1
Abstract: Emerging and re-emerging viruses are a global health concern. Genome sequencing as an approach for monitoring circulating viruses is currently hampered by complex and expensive methods. Untargeted, metagenomic nanopore sequencing can provide genomic information to… read more here.
Keywords: genome coverage; genome sequencing; rapid smart; nanopore sequencing ... See more keywords