OC-062 A whole genome crispr knockout screen and murine endoscopy identifies foxf1 as a key suppressor of colorectal cancer metastasis that acts through mtorc signalling
Sign Up to like & getrecommendations! Published in 2017 at "Gut"
DOI: 10.1136/gutjnl-2017-314472.62
Abstract: Introduction The proportion of patients with metastatic with colorectal cancer (CRC) who are cured of their disease is increasingly, but still low. The spread of cells from the primary tumour to distant sites is a… read more here.
Keywords: whole genome; genome crispr; colorectal cancer; metastasis ... See more keywords
Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022015629
Abstract: Calreticulin (CALR) mutations are important disease-initiating drivers of myeloproliferative neoplasms (MPNs) and cause hyperproliferation by binding to the thrombopoietin (TPO) receptor and inducing cytokine independent signaling. Jutzi and colleagues report on a CRISPR knockout screen… read more here.
Keywords: calr; genome crispr; glycosylation; calr mutant ... See more keywords