Polyploidization: Consequences of genome doubling on the evolutionary potential of populations.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of botany"
DOI: 10.1002/ajb2.16029
Abstract: Whole-genome duplication is common in plants and is considered to have a broad range of effects on individuals' phenotypes and genomes, and as an important driver of plant adaptation and speciation. Despite their increased capacity… read more here.
Keywords: consequences genome; genome doubling; heritable variance; evolutionary potential ... See more keywords
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02002-4
Abstract: Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to… read more here.
Keywords: tolerance; genome doubling; induces centrosome; genome ... See more keywords
Cyclin D mediates tolerance of genome-doubling in cancers with functional p53
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdw612
Abstract: Abstract Background Aneuploidy and chromosomal instability (CIN) are common features of human malignancy that fuel genetic heterogeneity. Although tolerance to tetraploidization, an intermediate state that further exacerbates CIN, is frequently mediated by TP53 dysfunction, we… read more here.
Keywords: genome doubling; cyclin; functional p53; type ... See more keywords
Development of homozygous tetraploid potato and whole genome doubling-induced the enrichment of H3K27ac and potentially enhanced resistance to cold-induced sweetening in tubers
Sign Up to like & getrecommendations! Published in 2023 at "Horticulture Research"
DOI: 10.1093/hr/uhad017
Abstract: Abstract Polyploid plants typically display advantages on some agronomically important traits over their diploid counterparts. Extensive studies have shown genetic, transcriptomic, and epigenetic dynamics upon polyploidization in multiple plant species. However, few studies have unveiled… read more here.
Keywords: potato; genome doubling; enrichment h3k27ac; genome ... See more keywords
A balancing act: how whole-genome doubling and aneuploidy interact in human cancer
Sign Up to like & getrecommendations! Published in 2023 at "Oncotarget"
DOI: 10.18632/oncotarget.28374
Abstract: Aneuploidy, or an abnormal chromosome copy number, is a characteristic feature of cancer, which plays an important role in cancer initiation and progression [1]. Aneuploidy prevalence patterns are tissue-specific, with different chromosomes gained or lost… read more here.
Keywords: genome doubling; whole genome; wgd; cancer ... See more keywords
Cyclin E2 Promotes Whole Genome Doubling in Breast Cancer
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DOI: 10.3390/cancers12082268
Abstract: Genome doubling is an underlying cause of cancer cell aneuploidy and genomic instability, but few drivers have been identified for this process. Due to their physiological roles in the genome reduplication of normal cells, we… read more here.
Keywords: cyclin; genome doubling; genome; breast cancer ... See more keywords