The regulatory landscape of genetically engineered crops in Pakistan
Sign Up to like & getrecommendations! Published in 2024 at "Food and Energy Security"
DOI: 10.1002/fes3.494
Abstract: Genome editing technology has become part and parcel of biotechnological approach to understand the genetic basis of different biological processes in an organism and for its application in different fields. The basic need of world… read more here.
Keywords: genome edited; genetically engineered; edited crops; act ... See more keywords
Legislation governing genetically modified and genome‐edited crops in Europe: the need for change
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Science of Food and Agriculture"
DOI: 10.1002/jsfa.9227
Abstract: Abstract The European Commission's assessment and approval process for genetically modified (GM) crops has resulted in only two GM crop varieties being licensed for cultivation in the European Union, one of which has been withdrawn.… read more here.
Keywords: genome edited; edited crops; genetically modified; european union ... See more keywords
Isolation and Analysis of a Genome-Edited Single-Hepatocyte from a Cas9 Transgenic Mouse Line.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8831-0_15
Abstract: The primary cells isolated from the freshly dissected organ are thought to be different from those cultured for a long time in vitro. For instance, hepatocytes isolated in situ from the liver, display the ability… read more here.
Keywords: genome edited; analysis; edited single; genome ... See more keywords
Affected Genome Editing Crops: The Consequences of Genome-Edited Babies in China
Sign Up to like & getrecommendations! Published in 2020 at "Science and Engineering Ethics"
DOI: 10.1007/s11948-020-00201-9
Abstract: Though genome editing (GE) is a powerful technology, germline GE engineering is strongly objectionable for a huge ethical challenge. The after-effects of the genome-edited babies incident have been emerging in China, whether technology or ethics.… read more here.
Keywords: edited babies; genome editing; genome edited; affected genome ... See more keywords
Genome edited intestine liver on a chip system for integrated intestinal hepatic drug absorption and metabolism evaluation
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-22425-0
Abstract: Evaluation of the intestinal absorption and hepatic metabolism is crucial to the development of orally administered drugs. Previous evaluation systems have assessed intestinal epithelial cells and hepatocytes separately. To develop an experimental system that accounts… read more here.
Keywords: genome edited; drug; metabolism; absorption ... See more keywords
Genome-edited livestock to secure sustainability
Sign Up to like & getrecommendations! Published in 2024 at "Reproduction, Fertility and Development"
DOI: 10.1071/rd24145
Abstract: Sustainable improvement of production in most tropical dairy systems is a significant challenge, because the cattle breeds with the most genetic potential for milk output relative to native tropical breeds have not been selected for… read more here.
Keywords: livestock secure; genome edited; edited livestock; genome ... See more keywords
Generation of genome-edited chicken and duck lines by adenovirus-mediated in vivo genome editing
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214344119
Abstract: Conventional avian genome editing is mediated by isolation, culture, and genome editing of primordial germ cells (PGCs); screening and propagating the genome-edited PGCs; and transplantation of the PGCs into recipient embryos. The PGC-mediated procedures, however,… read more here.
Keywords: genome editing; genome edited; duck lines; chicken duck ... See more keywords
Identification of genome edited cells using CRISPRnano
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac440
Abstract: Abstract Genome engineering-induced cleavage sites can be resolved by non-homologous end joining (NHEJ) or homology-directed repair (HDR). Identifying genetically modified clones at the target locus remains an intensive and laborious task. Different workflows and software… read more here.
Keywords: cells using; identification genome; genome edited; identification ... See more keywords
Abstract 1432: Enhanced effector responses of regenerated CAR-T cells derived from genome edited iPSCs
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-1432
Abstract: Chimeric antigen receptor (CAR) is an artificial protein that provides HLA-independent antigen specificity to T cells. CAR-T therapy has shown remarkable clinical responses especially in hematologic malignancies. But this therapy requires cell preparation for each… read more here.
Keywords: regenerated car; genome edited; car cells; car ... See more keywords
Regulatory Considerations for Genome-Edited T-cell Therapies.
Sign Up to like & getrecommendations! Published in 2024 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-24-0482
Abstract: Methods to engineer the genomes of human cells for therapeutic intervention continue to advance at a remarkable pace. Chimeric antigen receptor-engineered T lymphocytes have pioneered the way for these therapies, initially beginning with insertions of… read more here.
Keywords: regulatory considerations; genome edited; cell therapies; cell ... See more keywords
In Vivo Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2023 at "Cell Transplantation"
DOI: 10.1177/09636897231173734
Abstract: Human induced pluripotent stem cells (iPSCs) have already been used in transplantation therapies. Currently, cells from healthy people are transplanted into patients with diseases. With the rapid evolution of genome editing technology, genetic modification could… read more here.
Keywords: pluripotent stem; genome edited; therapeutic molecules; induced pluripotent ... See more keywords