Legislation governing genetically modified and genome‐edited crops in Europe: the need for change
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Science of Food and Agriculture"
DOI: 10.1002/jsfa.9227
Abstract: Abstract The European Commission's assessment and approval process for genetically modified (GM) crops has resulted in only two GM crop varieties being licensed for cultivation in the European Union, one of which has been withdrawn.… read more here.
Keywords: genome edited; edited crops; genetically modified; european union ... See more keywords
Isolation and Analysis of a Genome-Edited Single-Hepatocyte from a Cas9 Transgenic Mouse Line.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8831-0_15
Abstract: The primary cells isolated from the freshly dissected organ are thought to be different from those cultured for a long time in vitro. For instance, hepatocytes isolated in situ from the liver, display the ability… read more here.
Keywords: genome edited; analysis; edited single; genome ... See more keywords
Affected Genome Editing Crops: The Consequences of Genome-Edited Babies in China
Sign Up to like & getrecommendations! Published in 2020 at "Science and Engineering Ethics"
DOI: 10.1007/s11948-020-00201-9
Abstract: Though genome editing (GE) is a powerful technology, germline GE engineering is strongly objectionable for a huge ethical challenge. The after-effects of the genome-edited babies incident have been emerging in China, whether technology or ethics.… read more here.
Keywords: edited babies; genome editing; genome edited; affected genome ... See more keywords
Generation of genome-edited chicken and duck lines by adenovirus-mediated in vivo genome editing
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214344119
Abstract: Conventional avian genome editing is mediated by isolation, culture, and genome editing of primordial germ cells (PGCs); screening and propagating the genome-edited PGCs; and transplantation of the PGCs into recipient embryos. The PGC-mediated procedures, however,… read more here.
Keywords: genome editing; genome edited; duck lines; chicken duck ... See more keywords
Identification of genome edited cells using CRISPRnano
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac440
Abstract: Abstract Genome engineering-induced cleavage sites can be resolved by non-homologous end joining (NHEJ) or homology-directed repair (HDR). Identifying genetically modified clones at the target locus remains an intensive and laborious task. Different workflows and software… read more here.
Keywords: cells using; identification genome; genome edited; identification ... See more keywords
Abstract 1432: Enhanced effector responses of regenerated CAR-T cells derived from genome edited iPSCs
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-1432
Abstract: Chimeric antigen receptor (CAR) is an artificial protein that provides HLA-independent antigen specificity to T cells. CAR-T therapy has shown remarkable clinical responses especially in hematologic malignancies. But this therapy requires cell preparation for each… read more here.
Keywords: regenerated car; genome edited; car cells; car ... See more keywords
In Vivo Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2023 at "Cell Transplantation"
DOI: 10.1177/09636897231173734
Abstract: Human induced pluripotent stem cells (iPSCs) have already been used in transplantation therapies. Currently, cells from healthy people are transplanted into patients with diseases. With the rapid evolution of genome editing technology, genetic modification could… read more here.
Keywords: pluripotent stem; genome edited; therapeutic molecules; induced pluripotent ... See more keywords
Genome Edited Sirt1-Overexpressing Human Mesenchymal Stem Cells Exhibit Therapeutic Effects in Treating Collagen-Induced Arthritis
Sign Up to like & getrecommendations! Published in 2021 at "Molecules and Cells"
DOI: 10.14348/molcells.2021.0037
Abstract: Even though mesenchymal stem cells (MSCs) are known for cartilage regeneration, their therapeutic efficacy needs to be enhanced. In the present study, we produced genome-edited silent information regulator 2 type 1 (Sirt1)-overexpressing MSCs, and evaluated… read more here.
Keywords: genome edited; sirt1 overexpressing; collagen induced; stem cells ... See more keywords
Regulatory Status of Genome-Edited Organisms Under the Japanese Cartagena Act
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2019.00387
Abstract: The Japanese government recognizes the substantial values of genome-edited agricultural organisms and has defined in which cases these are covered by the existing regulatory framework to handle this technology. Genome-editing technologies could revolutionize and accelerate… read more here.
Keywords: genome edited; status genome; japanese cartagena; regulatory status ... See more keywords
Genome-edited TaTFL1-5 mutation decreases tiller and spikelet numbers in common wheat
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1142779
Abstract: Tillering is a critical agronomic trait of wheat (Triticum aestivum L.) that determines the shoot architecture and affects grain yield. TERMINAL FLOWER 1 (TFL1), encoding a phosphatidylethanolamine-binding protein, is implicated in the transition to flowering… read more here.
Keywords: number per; wheat; genome edited; spikelet ... See more keywords
Genome-Edited Plants: Opportunities and Challenges for an Anticipatory Detection and Identification Framework
Sign Up to like & getrecommendations! Published in 2021 at "Foods"
DOI: 10.3390/foods10020430
Abstract: It is difficult to trace and identify genome-edited food and feed products if relevant information is not made available to competent authorities. This results in major challenges, as genetically modified organism (GMO) regulatory frameworks for… read more here.
Keywords: genome edited; detection; framework; food feed ... See more keywords