Refining CRISPR-based genome and epigenome editing off-targets
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-019-09482-8
Abstract: To date, it has been broadly demonstrated and well proven that the CRISPR-derived genome and epigenome edit ing technologies have completely revolutionised and significantly accelerated discoveries and breakthroughs in gene therapy, animal modelling, drug screening,… read more here.
Keywords: gene editing; crispr; target; genome epigenome ... See more keywords
Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00958
Abstract: Base editors are tools that chemically modify the nucleobases of DNA and RNA in a programmable manner, allowing for genome, epigenome, and transcriptome editing in live cells. These tools can be used to introduce specific… read more here.
Keywords: transcriptome editing; base editors; genome epigenome; editing via ... See more keywords
Defining interactions between the genome, epigenome, and the environment in inflammatory bowel disease: progress and prospects.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.03.238
Abstract: Recent advances in our understanding of the pathogenesis of inflammatory bowel disease (IBD) have highlighted the complex interplay between the genome, epigenome and the environment. Despite of the exciting advances in genomics that have enabled… read more here.
Keywords: environment; disease; inflammatory bowel; epigenome environment ... See more keywords