Causality in transcription and genome folding: Insights from X inactivation
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DOI: 10.1002/bies.202200105
Abstract: The spatial organization of genomes is becoming increasingly understood. In mammals, where it is most investigated, this organization ties in with transcription, so an important research objective is to understand whether gene activity is a… read more here.
Keywords: genome folding; transcription genome; inactivation; causality transcription ... See more keywords
Predicting 3D genome folding from DNA sequence with Akita
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DOI: 10.1038/s41592-020-0958-x
Abstract: In interphase, the human genome sequence folds in three dimensions into a rich variety of locus-specific contact patterns. Cohesin and CTCF are key regulators; perturbing the levels of either greatly disrupts genome-wide folding as assayed… read more here.
Keywords: genome folding; predicting genome; folding dna; dna sequence ... See more keywords
3D epigenomics and 3D epigenopathies
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DOI: 10.5483/bmbrep.2023-0249
Abstract: Mammalian genomes are intricately compacted to form sophisticated 3-dimensional structures within the tiny nucleus, so called 3D genome folding. Despite their shapes reminiscent of an entangled yarn, the rapid development of molecular and next-generation sequencing… read more here.
Keywords: epigenomics epigenopathies; genome folding;