Genome-Guided Discovery of Antifungal Filipins from a Deep-Sea-Derived Streptomyces antibioticus.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00952
Abstract: Nine new (1-3, 5-8, 11, and 12; named filipins VI-XIV) and three known (4, 9, and 10) filipin-type polyene macrolides were isolated from the deep-sea-derived Streptomyces antibioticus OUCT16-23 using a genome-guided strategy coupled with bioassay.… read more here.
Keywords: streptomyces antibioticus; deep sea; sea derived; derived streptomyces ... See more keywords
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.3c00063
Abstract: In this study, an unprecedented myxobacterial siderophore termed sorangibactin was discovered by heterologous expression of a coelibactin-like nonribosomal peptide synthetase (NRPS) gene cluster from the Sorangiineae strain MSr11367 in the host Myxococcus xanthus DK1622. De… read more here.
Keywords: myxobacterial thiolactone; discovery myxobacterial; guided discovery; thiolactone ... See more keywords
The effect of fampridine on working memory: a randomized controlled trial based on a genome-guided repurposing approach
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Psychiatry"
DOI: 10.1038/s41380-024-02820-1
Abstract: Working memory (WM), a key component of cognitive functions, is often impaired in psychiatric disorders such as schizophrenia. Through a genome-guided drug repurposing approach, we identified fampridine, a potassium channel blocker used to improve walking… read more here.
Keywords: fampridine; working memory; genome guided; repurposing approach ... See more keywords
A genome-guided strategy for climate resilience in American chestnut restoration populations
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2403505121
Abstract: Significance Many forest tree species are vulnerable to the extreme effects of climate change, and in the absence of intervention, to extinction. Because of chronic fungal blight infections, American chestnut trees in the eastern United… read more here.
Keywords: chestnut; climate; restoration; genome guided ... See more keywords
Genome-guided purification of high amounts of the siderophore ornibactin and detection of potentially novel burkholdine derivatives produced by Burkholderia catarinensis 89T.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of applied microbiology"
DOI: 10.1093/jambio/lxae040
Abstract: AIM The increased availability of genome sequences has enabled the development of valuable tools for the prediction and identification of bacterial natural products. Burkholderia catarinensis 89T produces siderophores and an unknown potent antifungal metabolite. The… read more here.
Keywords: catarinensis; burkholderia catarinensis; genome; genome guided ... See more keywords
Lung adenocarcinoma: from molecular basis to genome-guided therapy and immunotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2017.06.20
Abstract: Although adenocarcinoma (ADC) is the most frequent lung cancer, its diagnosis is often late, when the local invasion is important and/or the metastases have already appeared. Therefore, the mortality at 5 years is still very… read more here.
Keywords: therapy immunotherapy; guided therapy; genome guided; lung ... See more keywords
Genome-Guided Analysis of Seven Weed Species Reveals Conserved Sequence and Structural Features of Key Gene Targets for Herbicide Development
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.909073
Abstract: Herbicides are commonly deployed as the front-line treatment to control infestations of weeds in native ecosystems and among crop plants in agriculture. However, the prevalence of herbicide resistance in many species is a major global… read more here.
Keywords: gene; development; weed species; genome guided ... See more keywords
Genome Guided Personalized Drug Therapy in Attention Deficit Hyperactivity Disorder
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.925442
Abstract: ADHD is a common behavioral syndrome with a heritability of 70–80%. Genome wide sequencing and association studies indicate that ADHD risk variants are distributed across a wide range of allele frequencies and relative risks. Several… read more here.
Keywords: adhd; genome; risk; personalized drug ... See more keywords
Genome-Guided Discovery of the First Myxobacterial Biarylitide Myxarylin Reveals Distinct C–N Biaryl Crosslinking in RiPP Biosynthesis
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26247483
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a structurally diverse group of natural products. They feature a wide range of intriguing post-translational modifications, as exemplified by the biarylitides. These are a family of cyclic… read more here.
Keywords: guided discovery; myxarylin; biarylitide; biaryl ... See more keywords