The age‐related decline of helicase function—how G‐quadruplex structures promote genome instability
Sign Up to like & getrecommendations! Published in 2024 at "Febs Letters"
DOI: 10.1002/1873-3468.14939
Abstract: The intricate mechanisms underlying transcription‐dependent genome instability involve G‐quadruplexes (G4) and R‐loops. This perspective elucidates the potential link between these structures and genome instability in aging. The co‐occurrence of G4 DNA and RNA–DNA hybrid structures… read more here.
Keywords: related decline; genome instability; age related; instability ... See more keywords
Biomarkers of genome instability in normal mammalian genomes following drug‐induced replication stress
Sign Up to like & getrecommendations! Published in 2020 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22364
Abstract: Genome instability is a hallmark of most human cancers and is exacerbated following replication stress. However, the effects that drugs/xenobiotics have in promoting genome instability including chromosomal structural rearrangements in normal cells are not currently… read more here.
Keywords: drug induced; toxicology; genome instability; replication stress ... See more keywords
Defining R-loop classes and their contributions to genome instability.
Sign Up to like & getrecommendations! Published in 2021 at "DNA repair"
DOI: 10.1016/j.dnarep.2021.103182
Abstract: R-loops are non-B DNA structures that form during transcription when the nascent RNA anneals to the template DNA strand forming a RNA:DNA hybrid. Understanding the genomic distribution and function of R-loops is an important goal,… read more here.
Keywords: defining loop; class; genome instability; loop classes ... See more keywords
Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2016.07.014
Abstract: DNA repair defects create cancer predisposition in humans by fostering a higher rate of mutations. While DNA repair is quite well characterized, recent studies have identified previously unrecognized relationships between DNA repair and R-loop-mediated genome… read more here.
Keywords: genome instability; loop; dna repair; repair ... See more keywords
LMNB1 mutation causes cerebellar involvement and a genome instability defect
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.06.027
Abstract: Please cite this article as: José Luiz Pedroso, Veridiana Munford, André Uchimura Bastos, Ligia Pereira de Castro, Victor Hugo Rocha Marussi, Gisele Sampaio Silva, Juliana Harumi Arita, Carlos F.M. Menck, Orlando G. Barsottini , LMNB1… read more here.
Keywords: lmnb1 mutation; cerebellar involvement; genome instability; causes cerebellar ... See more keywords
Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability
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DOI: 10.1038/s41467-024-54547-w
Abstract: Chromothripsis is a frequent form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of one or multiple chromosome(s). However, little is known about the heterogeneity of chromothripsis across different clones… read more here.
Keywords: genomic transcriptomic; chromothripsis; genome instability; single cell ... See more keywords
RNA: a double-edged sword in genome maintenance
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Genetics"
DOI: 10.1038/s41576-020-0263-7
Abstract: All organisms must safeguard the integrity of their DNA to avoid deleterious consequences of genome instability, which have been linked to human diseases such as autoimmune disorders, neurodegenerative diseases and cancer. Traditionally, genome maintenance has… read more here.
Keywords: genome maintenance; maintenance; rna double; genome instability ... See more keywords
Genome instability drives epistatic adaptation in the human pathogen Leishmania.
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113744118
Abstract: How genome instability is harnessed for fitness gain despite its potential deleterious effects is largely elusive. An ideal system to address this important open question is provided by the protozoan pathogen Leishmania, which exploits frequent… read more here.
Keywords: genome instability; gene; adaptation; pathogen leishmania ... See more keywords
Oxidation resistance 1 prevents genome instability through maintenance of G2/M arrest in gamma-ray-irradiated cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrz080
Abstract: ABSTRACT Human oxidation resistance 1 (OXR1) was identified as a protein that decreases genomic mutations in Escherichia coli caused by oxidative DNA damage. However, the mechanism by which OXR1 defends against genome instability has not… read more here.
Keywords: oxr1 depleted; genome instability; depleted cells; oxidation resistance ... See more keywords
VID22 counteracts G-quadruplex-induced genome instability
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1156
Abstract: Abstract Genome instability is a condition characterized by the accumulation of genetic alterations and is a hallmark of cancer cells. To uncover new genes and cellular pathways affecting endogenous DNA damage and genome integrity, we… read more here.
Keywords: dna; genome instability; vid22 counteracts; dna damage ... See more keywords
Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab965
Abstract: Abstract Loss of telomeric DNA leads to telomere uncapping, which triggers a persistent, p53-centric DNA damage response that sustains a stable senescence-associated proliferation arrest. Here, we show that in normal cells telomere uncapping triggers a… read more here.
Keywords: telomeric dna; dna; homologous recombination; senescence ... See more keywords