DTYMK is essential for genome integrity and neuronal survival
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02394-0
Abstract: Nucleotide metabolism is a complex pathway regulating crucial cellular processes such as nucleic acid synthesis, DNA repair and proliferation. This study shows that impairment of the biosynthesis of one of the building blocks of DNA,… read more here.
Keywords: neuronal survival; essential genome; genome integrity; genome ... See more keywords
Nuclear actin and myosin in chromatin regulation and maintenance of genome integrity.
Sign Up to like & getrecommendations! Published in 2020 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2020.05.001
Abstract: Cytoskeletal proteins are beginning to be considered as key regulators of nuclear function. Among them, actin and myosin have been implicated in numerous tasks, including chromatin regulation, transcription and assembly of nascent ribonucleoprotein complexes. We… read more here.
Keywords: maintenance genome; chromatin regulation; myosin; genome integrity ... See more keywords
DCAF14 promotes stalled fork stability to maintain genome integrity
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108669
Abstract: SUMMARY Replication stress response ensures impediments to DNA replication do not compromise replication fork stability and genome integrity. In a process termed replication fork protection, newly synthesized DNA at stalled replication forks is stabilized and… read more here.
Keywords: stalled fork; fork stability; fork; genome integrity ... See more keywords
Proteolytic control of genome integrity at the replication fork.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.102657
Abstract: Faithful duplication of the genome is critical for the survival of an organism and prevention of malignant transformation. Accurate replication of a large amount of genetic information in a timely manner is one of the… read more here.
Keywords: replication fork; dna replication; replication; genome integrity ... See more keywords
The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01049-7
Abstract: Transposable elements (TEs) contribute to the large amount of repetitive sequences in mammalian genomes and have been linked to species-specific genome innovations by rewiring regulatory circuitries. However, organisms need to restrict TE activity to ensure… read more here.
Keywords: transposon invasion; emergence pirnas; integrity; pirnas transposon ... See more keywords
A lncRNA GUARDINg genome integrity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0075-6
Abstract: A coordinated DNA damage response mediated by p53 to repair DNA lesions or to promote apoptosis is essential for maintenance of genome stability. A study now unveils the long non-coding RNA GUARDIN as a component… read more here.
Keywords: integrity; biology; genome integrity; guarding genome ... See more keywords
Preserving genome integrity in human cells via DNA double-strand break repair
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-10-0668
Abstract: The efficient maintenance of genome integrity in the face of cellular stress is vital to protect against human diseases such as cancer. DNA replication, chromatin dynamics, cellular signaling, nuclear architecture, cell cycle checkpoints, and other… read more here.
Keywords: double strand; human cells; dna double; genome integrity ... See more keywords
Ataxin-3 promotes genome integrity by stabilizing Chk1
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx095
Abstract: Abstract The Chk1 protein is essential for genome integrity maintenance and cell survival in eukaryotic cells. After prolonged replication stress, Chk1 can be targeted for proteasomal degradation to terminate checkpoint signaling after DNA repair finishes.… read more here.
Keywords: chk1; dna; atx3; genome integrity ... See more keywords
Base excision repair but not DNA double‐strand break repair is impaired in aged human adipose‐derived stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Aging Cell"
DOI: 10.1111/acel.13062
Abstract: The decline in DNA repair capacity contributes to the age‐associated decrease in genome integrity in somatic cells of different species. However, due to the lack of clinical samples and appropriate tools for studying DNA repair,… read more here.
Keywords: stem cells; dna; genome integrity; adipose derived ... See more keywords
Abstract 2074: Genome Integrity assessment and verification by optical genome mapping for cell manufacturing/bioprocessing applications
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2074
Abstract: Cells and cell lines are used for multiple applications such as bioprocessing, therapy, and research. To ensure quality of cells and downstream applications, appropriate quality control (QC) methods are critical. Historically, karyotyping has been employed,… read more here.
Keywords: cell; genome mapping; genome; optical genome ... See more keywords
Genome concentration, characterization, and integrity analysis of recombinant adeno-associated viral vectors using droplet digital PCR
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280242
Abstract: Precise, reproducible characterization of AAV is critical for comparing preclinical results between laboratories and determining a safe and effective clinical dose for gene therapy applications. In this study, we systematically evaluated numerous parameters to produce… read more here.
Keywords: genome integrity; concentration; analysis; integrity ... See more keywords