Linking the organization of DNA replication with genome maintenance
Sign Up to like & getrecommendations! Published in 2018 at "Current Genetics"
DOI: 10.1007/s00294-018-0923-8
Abstract: The spatial and temporal organization of genome duplication, also referred to as the replication program, is defined by the distribution and the activities of the sites of replication initiation across the genome. Alterations to the… read more here.
Keywords: genome maintenance; dna replication; replication; organization ... See more keywords
RNA: a double-edged sword in genome maintenance
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Genetics"
DOI: 10.1038/s41576-020-0263-7
Abstract: All organisms must safeguard the integrity of their DNA to avoid deleterious consequences of genome instability, which have been linked to human diseases such as autoimmune disorders, neurodegenerative diseases and cancer. Traditionally, genome maintenance has… read more here.
Keywords: genome maintenance; maintenance; rna double; genome instability ... See more keywords
Genome Maintenance in Mammalian Stem Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of genetics"
DOI: 10.1146/annurev-genet-072920-022154
Abstract: Various stem cells in the body are tasked with maintaining tissue homeostasis throughout the life of an organism and thus must be resilient to intrinsic and extrinsic challenges such as infection and injury. Crucial to… read more here.
Keywords: cell; genome maintenance; stem; stem cells ... See more keywords
Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011039
Abstract: Merkel cell polyomavirus (MCV) is a small DNA tumor virus that persists in human skin and causes Merkel cell carcinoma (MCC) in immunocompromised individuals. The multi-functional protein MCV small T (sT) activates viral DNA replication… read more here.
Keywords: merkel cell; maintenance; cell polyomavirus; expression ... See more keywords
The Critical Role of Genome Maintenance Proteins in Immune Evasion During Gammaherpesvirus Latency
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.03315
Abstract: Gammaherpesviruses are important pathogens that establish latent infection in their natural host for lifelong persistence. During latency, the viral genome persists in the nucleus of infected cells as a circular episomal element while the viral… read more here.
Keywords: gammaherpesvirus; genome maintenance; latency; immune evasion ... See more keywords
From Processivity to Genome Maintenance: The Many Roles of Sliding Clamps
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13112058
Abstract: Sliding clamps play a pivotal role in the process of replication by increasing the processivity of the replicative polymerase. They also serve as an interacting platform for a plethora of other proteins, which have an… read more here.
Keywords: maintenance many; processivity genome; genome maintenance; sliding clamps ... See more keywords
The Nucleolus: In Genome Maintenance and Repair
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18071411
Abstract: The nucleolus is the subnuclear membrane-less organelle where rRNA is transcribed and processed and ribosomal assembly occurs. During the last 20 years, however, the nucleolus has emerged as a multifunctional organelle, regulating processes that go… read more here.
Keywords: maintenance repair; genome maintenance; dna; nucleolus genome ... See more keywords
Genome maintenance in retinoblastoma: Implications for therapeutic vulnerabilities
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13312
Abstract: Retinoblastoma (RB) is a pediatric ocular malignancy that is initiated mostly by biallelic inactivation of the RB transcriptional corepressor 1 (RB1) tumor suppressor gene in the developing retina. Unlike the prevailing prediction based on multiple… read more here.
Keywords: maintenance; maintenance retinoblastoma; genome maintenance; maintenance mechanisms ... See more keywords