An Overview on Nocardiopsis Species Originating From North African Biotopes as a Promising Source of Bioactive Compounds and In Silico Genome Mining Analysis of Three Sequenced Genomes
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.202400046
Abstract: Actinobacteria are renowned for their prolific production of diverse bioactive secondary metabolites. In recent years, there has been an increasing focus on exploring “rare” genera within this phylum for biodiscovery purposes, notably the Nocardiopsis genus,… read more here.
Keywords: mining analysis; genome mining; north african; nocardiopsis ... See more keywords
Genome mining and homologous comparison strategy for digging exporters contributing self-resistance in natamycin-producing Streptomyces strains
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10131-7
Abstract: As antibiotics are always toxic to the antibiotic-producing strains themselves, most Streptomyces strains have evolved several self-resistance mechanisms, among which the antibiotic efflux system is understood best and is commonly found. Among the efflux systems,… read more here.
Keywords: natamycin producing; producing streptomyces; streptomyces strains; genome mining ... See more keywords
Natural product discovery through microbial genome mining.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2020.07.010
Abstract: The advent of the genomic era has opened up enormous possibilities for the discovery of new natural products. Also known as specialized metabolites, these compounds produced by bacteria, fungi, and plants have long been sought… read more here.
Keywords: product discovery; biology; natural product; genome mining ... See more keywords
Fungal feruloyl esterases: Functional validation of genome mining based enzyme discovery including uncharacterized subfamilies.
Sign Up to like & getrecommendations! Published in 2018 at "New biotechnology"
DOI: 10.1016/j.nbt.2017.11.004
Abstract: Feruloyl esterases (FAEs) are a diverse group of enzymes that specifically catalyze the hydrolysis of ester bonds between a hydroxycinnamic (e.g. ferulic) acid and plant poly- or oligosaccharides. FAEs as auxiliary enzymes significantly assist xylanolytic… read more here.
Keywords: feruloyl esterases; faes; fungal faes; genome mining ... See more keywords
Perception of the Biocontrol Potential and Palmitic Acid Biosynthesis Pathway of Bacillus subtilis H2 through Merging Genome Mining with Chemical Analysis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c06411
Abstract: Bacillus has been widely studied for its potential to protect plants from pathogens. Here, we report the whole genome sequence of Bacillus subtilis H2, which was isolated from the tea garden soil of Guiyang Forest… read more here.
Keywords: bacillus; bacillus subtilis; genome; genome mining ... See more keywords
Genome Mining and Heterologous Expression-Guided Discovery of Mangicol Sesterterpenoids with Antimicrobial and Antineuroinflammatory Activities.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c04187
Abstract: The accelerating increase in antimicrobial resistance presents serious dangers to global health, food safety, and agricultural productivity. In this study, we explored fungal-derived sesterterpenoids as potential antimicrobial agents, focusing on mangicols biosynthesized by a newly… read more here.
Keywords: guided discovery; genome mining; expression guided; mangicol ... See more keywords
Expanding the Chemical Diversity of Fasamycin Via Genome Mining and Biocatalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c01089
Abstract: Genome mining and biocatalytic modification of chemical structures are critical methods to develop new antibiotics. In this study, eight new fasamycins (3, 4, 6, and 8-12) along with five known analogues (1, 2, 5, 7,… read more here.
Keywords: chemical diversity; genome mining;
Genome Mining Leads to Diverse Sesquiterpenes with Anti-inflammatory Activity from an Arctic-Derived Fungus.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.4c00237
Abstract: With the advancement of bioinformatics, the integration of genome mining with efficient separation technology enables the discovery of a greater number of novel bioactive compounds. The deletion of the key gene responsible for triterpene cyclase… read more here.
Keywords: leads diverse; mining leads; diverse sesquiterpenes; genome mining ... See more keywords
Incarnatapeptins A and B, Nonribosomal Peptides Discovered Using Genome Mining and 1H/15N HSQC-TOCSY.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00818
Abstract: Methods for the focused isolation of low-abundance natural products with specific chemical substructures could expand known bioactive chemical diversity for drug discovery. Here we report the combined use of genome mining and an 15N NMR-based… read more here.
Keywords: nonribosomal peptides; incarnatapeptins nonribosomal; mining 15n; genome mining ... See more keywords
Griseocazines: Neuroprotective Multiprenylated Cyclodipeptides Identified through Targeted Genome Mining.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00745
Abstract: Prenylation can impart pharmacological advantages to bioactive compounds. Global genome mining for prenylated cyclodipeptides identified a gczABC BGC from Streptomyces griseocarneus 132 containing a cyclodipeptide synthase and two prenyltransferase genes. Subsequent heterologous expression allowed isolation… read more here.
Keywords: neuroprotective multiprenylated; griseocazines neuroprotective; cyclodipeptides identified; genome mining ... See more keywords
Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01172
Abstract: Genome mining and bioinformatics analyses allowed us to rationally find a candidate biosynthetic gene cluster for a new cyclic depsipeptide of Chaetomium mollipilium. A heterologous reconstitution of the identified biosynthetic pathway predictably afforded a new… read more here.
Keywords: genome mining; cyclic depsipeptide; chaetomium mollipilium; depsipeptide ... See more keywords