Cytosolic microRNA-inducible nuclear translocation of Cas9 protein for disease-specific genome modification
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac431
Abstract: Abstract MicroRNA-dependent mRNA decay plays an important role in gene silencing by facilitating posttranscriptional and translational repression. Inspired by this intrinsic nature of microRNA-mediated mRNA cleavage, here, we describe a microRNA-targeting mRNA as a switch… read more here.
Keywords: translocation; genome modification; cas9 protein;
Capsid and Genome Modification Strategies to Reduce the Immunogenicity of Adenoviral Vectors
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22052417
Abstract: Adenovirus-based gene transfer vectors are the most frequently used vector type in gene therapy clinical trials to date, and they play an important role as genetic vaccine candidates during the ongoing SARS-CoV-2 pandemic. Immediately upon… read more here.
Keywords: genome modification; modification strategies; immunogenicity adenoviral; reduce immunogenicity ... See more keywords