Spatial genome organization, TGFβ, and biomolecular condensates: Do they talk during development?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200145
Abstract: Cis‐regulatory elements govern gene expression programs to determine cell identity during development. Recently, the possibility that multiple enhancers are orchestrated in clusters of enhancers has been suggested. How these elements are arranged in the 3D… read more here.
Keywords: development; spatial genome; tgf biomolecular; organization tgf ... See more keywords
Comparative Methods for Reconstructing Ancient Genome Organization.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7463-4_13
Abstract: Comparative genomics considers the detection of similarities and differences between extant genomes, and, based on more or less formalized hypotheses regarding the involved evolutionary processes, inferring ancestral states explaining the similarities and an evolutionary history… read more here.
Keywords: methods reconstructing; comparative methods; reconstructing ancient; ancient genome ... See more keywords
The complete nucleotide sequence and genome organization of a novel betaflexivirus infecting Citrullus lanatus
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Virology"
DOI: 10.1007/s00705-017-3461-7
Abstract: The complete nucleotide sequence of a novel positive single-stranded (+ss) RNA virus, tentatively named watermelon virus A (WVA), was determined using a combination of three methods: RNA sequencing, small RNA sequencing, and Sanger sequencing. The… read more here.
Keywords: nucleotide sequence; complete nucleotide; organization novel; sequence genome ... See more keywords
Genome dimensions control biological and toxicological functions; myth or reality?
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-018-9440-2
Abstract: The multidimensional genome offers a new perspective to understand molecular mechanisms of genotoxicity and provide deeper knowledge of how genome organization and reorganization in dimensions can alter cell sensitivity, tolerance, resistance, or toxicity to drugs,… read more here.
Keywords: control biological; genome dimensions; genome; dimensions control ... See more keywords
Evolution of genome organization and epigenetic machineries
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biosciences"
DOI: 10.1007/s12038-018-9742-9
Abstract: The unit content of DNA in a living organism containing all of its genes is referred to as ‘genome’, which forms the basis of life and heredity. In the path of evolution from a single-cellular… read more here.
Keywords: organization epigenetic; eukaryotic system; epigenetic machineries; size ... See more keywords
Genome organization at different scales: nature, formation and function.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.03.009
Abstract: Since the discovery of chromosome territories, it has been clear that DNA within the nucleus is spatially organized. During the last decade, a tremendous body of work has described architectural features of chromatin at different… read more here.
Keywords: different scales; formation; organization different; scales nature ... See more keywords
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109722
Abstract: DNA replication timing and three-dimensional (3D) genome organization are associated with distinct epigenome patterns across large domains. However, whether alterations in the epigenome, in particular cancer-related DNA hypomethylation, affects higher-order levels of genome architecture is… read more here.
Keywords: replication timing; replication; dna replication; genome organization ... See more keywords
Metabolites, genome organization, and cellular differentiation gene programs.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.01.005
Abstract: The nutrient environment and metabolism play a dynamic role in cellular differentiation and research is elucidating the mechanisms that contribute to this process. Metabolites serve as an effective bridge that helps to translate information about… read more here.
Keywords: metabolites genome; cellular differentiation; differentiation; organization ... See more keywords
Genome Organization: Cohesin on the Move.
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DOI: 10.1016/j.molcel.2017.05.002
Abstract: Folding of mammalian genomes into spatial domains is thought to depend on cohesin and CTCF proteins. Busslinger et al. (2017) reveal that transcription moves cohesin along DNA to CTCF-binding sites, providing insights into how cohesin and CTCF… read more here.
Keywords: organization cohesin; cohesin; cohesin move; ctcf ... See more keywords
Three-dimensional genome organization in epigenetic regulations: cause or consequence?
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2021.102031
Abstract: The evolution of the nucleus is an evolutionary milestone. By enabling genome compartmentalization, it contributes to the fine-tuning of genome functions. The genome is partitioned into functional domains differing in spatial positioning and topological folding… read more here.
Keywords: three dimensional; dimensional genome; cause consequence; genome ... See more keywords
Comparative analysis of 2D and 3D distance measurements to study spatial genome organization.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2017.01.007
Abstract: The spatial organization of genomes is non-random, cell-type specific, and has been linked to cellular function. The investigation of spatial organization has traditionally relied extensively on fluorescence microscopy. The validity of the imaging methods used… read more here.
Keywords: distance measurements; distance; analysis; spatial genome ... See more keywords