Adaptive laboratory evolution of a genome-reduced Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08888-6
Abstract: Synthetic biology aims to design and construct bacterial genomes harboring the minimum number of genes required for self-replicable life. However, the genome-reduced bacteria often show impaired growth under laboratory conditions that cannot be understood based… read more here.
Keywords: laboratory evolution; biology; laboratory; adaptive laboratory ... See more keywords
Genome-scale top-down strategy to generate viable genome-reduced phages
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1168
Abstract: Abstract Efforts have been made to reduce the genomes of living cells, but phage genome reduction remains challenging. It is of great interest to investigate whether genome reduction can make phages obtain new infectious properties.… read more here.
Keywords: genome reduced; genome; genome reduction; genome scale ... See more keywords
Rational Design of Live-Attenuated Vaccines against Genome-Reduced Pathogens
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DOI: 10.1128/spectrum.03776-22
Abstract: Identification of bacterial genes that are specifically upregulated during infection can lead to the rational construction of live vaccines. For this purpose, genome-based approaches, including DNA microarray analysis and IVET (in vivo expression technology), have… read more here.
Keywords: upregulated infection; genome reduced; infection; live vaccines ... See more keywords
Developing genome-reduced Pseudomonas chlororaphis strains for the production of secondary metabolites
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DOI: 10.1186/s12864-017-4127-2
Abstract: BackgroundThe current chassis organisms or various types of cell factories have considerable advantages and disadvantages. Therefore, it is necessary to develop various chassis for an efficient production of different bioproducts from renewable resources. In this… read more here.
Keywords: pseudomonas chlororaphis; production; chassis; chlororaphis ... See more keywords
Microbial Valorization of Lignin to Bioplastic by Genome-Reduced Pseudomonas putida
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.923664
Abstract: As the most abundant natural aromatic resource, lignin valorization will contribute to a feasible biobased economy. Recently, biological lignin valorization has been advocated since ligninolytic microbes possess proficient funneling pathways of lignin to valuable products.… read more here.
Keywords: lignin; genome reduced; valorization; reduced pseudomonas ... See more keywords