Structural and functional conservation of cis-acting RNA elements in coronavirus 5'-terminal genome regions
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DOI: 10.1016/j.virol.2017.11.025
Abstract: Abstract Structure predictions suggest a partial conservation of RNA structure elements in coronavirus terminal genome regions. Here, we determined the structures of stem-loops (SL) 1 and 2 of two alphacoronaviruses, human coronavirus (HCoV) 229E and… read more here.
Keywords: terminal genome; conservation; hcov 229e; elements coronavirus ... See more keywords
Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions
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DOI: 10.1093/molbev/msw249
Abstract: Despite its population, geographic size, and emerging economic importance, disproportionately little genome-scale research exists into genetic factors that predispose Brazilians to disease, or the population genetics of risk. After identification of suitable proxy populations and… read more here.
Keywords: genome wide; analysis; highly differentiated; ancestry ... See more keywords
Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice
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DOI: 10.1186/s13059-018-1530-1
Abstract: CRISPR/dCas9 is a versatile tool that can be used to recruit various effectors and fluorescent molecules to defined genome regions where it can modulate genetic and epigenetic markers, or track the chromatin dynamics in live… read more here.
Keywords: knock mice; genome regions; dcas9 knock; crispr dcas9 ... See more keywords