Revealing the metabolic characteristics of human embryonic stem cells by genome‐scale metabolic modeling
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13255
Abstract: Embryonic stem cells (ESCs) are characterized by a dual capacity, self‐renewal and pluripotency, which can be regulated by metabolism. A better understanding of ESC metabolism and regulatory mechanisms is pivotal for research into development, ageing,… read more here.
Keywords: genome scale; metabolic characteristics; embryonic stem; stem ... See more keywords
Optimization of a modeling platform to predict oncogenes from genome‐scale metabolic networks of non‐small‐cell lung cancers
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13231
Abstract: Cancer cell dysregulations result in the abnormal regulation of cellular metabolic pathways. By simulating this metabolic reprogramming using constraint‐based modeling approaches, oncogenes can be predicted, and this knowledge can be used in prognosis and treatment.… read more here.
Keywords: genome scale; platform; expression; scale metabolic ... See more keywords
Genome-scale data resolves the timing of divergence in Joshua trees.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of botany"
DOI: 10.1002/ajb2.1633
Abstract: PREMISE Joshua trees (Yucca brevifolia and Y. jaegeriana) and their yucca moth pollinators (Tegeticula synthetica and T. antithetica) are a model system for studies of plant-pollinator coevolution and, they are thought to be one of… read more here.
Keywords: coevolution; genome scale; joshua trees; divergence ... See more keywords
Genome‐Scale Metabolic Reconstruction of Actinomycetes for Antibiotics Production
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Journal"
DOI: 10.1002/biot.201800377
Abstract: Systems biology approaches are increasingly applied to explore the potential of actinomycetes for the discovery and optimal production of antibiotics. In particular, genome‐scale metabolic models (GEMs) of various actinomycetes are reconstructed at a faster rate… read more here.
Keywords: reconstruction actinomycetes; genome scale; production; actinomycetes antibiotics ... See more keywords
Genome‐Scale Metabolic Model's multi‐objective solving algorithm based on the inflexion point of Pareto front including maximum energy utilization and its application in Aspergillus niger DS03043
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28078
Abstract: The solution of Genome‐Scale Metabolic Model (GSMM) directly affects the simulation accuracy of the metabolic process in digital cells. Single‐objective optimization methods, such as flux balance analysis (FBA), which is widely used in solving GSMM,… read more here.
Keywords: scale metabolic; multi objective; pareto front; gsmm ... See more keywords
How reliable are Chinese Hamster Ovary (CHO) cell genome-scale metabolic models?
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28366
Abstract: Genome-scale metabolic models (GEMs) possess the power to revolutionise bioprocess and cell line engineering workflows by their ability to predict and understand whole cell metabolism in silico. Despite this potential, it is unclear how accurately… read more here.
Keywords: scale metabolic; cell; cho cell; cho ... See more keywords
Whole‐genome sequencing and genome‐scale metabolic modeling of Chromohalobacter canadensis 85B to explore its salt tolerance and biotechnological use
Sign Up to like & getrecommendations! Published in 2022 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1328
Abstract: Salt tolerant organisms are increasingly being used for the industrial production of high‐value biomolecules due to their better adaptability compared to mesophiles. Chromohalobacter canadensis is one of the early halophiles to show promising biotechnology potential,… read more here.
Keywords: canadensis; genome sequencing; chromohalobacter canadensis; whole genome ... See more keywords
Synthesizing Systems Biology Knowledge from Omics Using Genome‐Scale Models
Sign Up to like & getrecommendations! Published in 2020 at "PROTEOMICS"
DOI: 10.1002/pmic.201900282
Abstract: Omic technologies have enabled the complete readout of the molecular state of a cell at different biological scales. In principle, the combination of multiple omic data types can provide an integrated view of the entire… read more here.
Keywords: genome scale; scale models; omic data; biology ... See more keywords
PANTHER: Making genome‐scale phylogenetics accessible to all
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4218
Abstract: Phylogenetics is a powerful tool for analyzing protein sequences, by inferring their evolutionary relationships to other proteins. However, phylogenetics analyses can be challenging: they are computationally expensive and must be performed carefully in order to… read more here.
Keywords: making genome; panther making; scale phylogenetics; genome scale ... See more keywords
A Protocol for the Construction and Curation of Genome-Scale Integrated Metabolic and Regulatory Network Models.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9142-6_14
Abstract: Genome-scale metabolic network models have been widely used over the last decade and have been shown to successfully predict the metabolic behavior of many organisms. Yet the complexity of metabolic regulation often limits the accuracy… read more here.
Keywords: metabolic regulatory; genome scale; network; network models ... See more keywords
A new strategy for dynamic metabolic flux estimation by integrating transient metabolome data into genome-scale metabolic models
Sign Up to like & getrecommendations! Published in 2021 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-021-02626-3
Abstract: Metabolic flux analysis (MFA) is a powerful tool for studying microbial cell physiology. Isotope-based MFA is the accepted standard for studying metabolic fluxes under steady-state conditions. However, its application under dynamic extracellular conditions is limited… read more here.
Keywords: metabolic flux; data genome; genome scale; physiology ... See more keywords