Cohesin — bridging the gap among gene transcription, genome stability, and human diseases
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Letters"
DOI: 10.1002/1873-3468.14949
Abstract: The intricate landscape of cellular processes governing gene transcription, chromatin organization, and genome stability is a fascinating field of study. A key player in maintaining this delicate equilibrium is the cohesin complex, a molecular machine… read more here.
Keywords: human diseases; gene transcription; genome stability;
Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.05.009
Abstract: SUMMARY The mammalian sirtuin, SIRT6, is a key tumor suppressor that maintains genome stability and regulates transcription, though how SIRT6 family members control genome stability is unclear. Here, we use multiple genome-wide approaches to demonstrate… read more here.
Keywords: genome stability; family members; maintain transcription; stability ... See more keywords
Cooperation between non-essential DNA polymerases contributes to genome stability in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.02.004
Abstract: DNA polymerases influence genome stability through their involvement in DNA replication, response to DNA damage, and DNA repair processes. Saccharomyces cerevisiae possess four non-essential DNA polymerases, Pol λ, Pol η, Pol ζ, and Rev1, which… read more here.
Keywords: genome stability; dna; non essential; dna polymerases ... See more keywords
Wolbachia Genome Stability and mtDNA Variants in Aedes aegypti Field Populations Eight Years after Release
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101572
Abstract: Summary A dengue suppression strategy based on release of Aedes aegypti mosquitoes infected with the bacterium Wolbachia pipientis is being trialed in many countries. Wolbachia inhibits replication and transmission of dengue viruses. Questions remain regarding… read more here.
Keywords: genome stability; wolbachia genome; aedes aegypti; field ... See more keywords
Linker histones and chromatin remodelling complexes maintain genome stability and control cellular ageing
Sign Up to like & getrecommendations! Published in 2019 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2018.07.002
Abstract: Linker histones are major players in chromatin organization and per se are essential players in genome homeostasis. As the fifth class of histone proteins the linker histones not only interact with DNA and core histones… read more here.
Keywords: linker histones; genome stability; linker; linker histone ... See more keywords
E2 Enzymes in Genome Stability: Pulling the Strings Behind the Scenes.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.01.009
Abstract: Ubiquitin and ubiquitin-like proteins (UBLs) function as critical post-translational modifiers in the maintenance of genome stability. Ubiquitin/UBL-conjugating enzymes (E2s) are responsible, as part of a wider enzymatic cascade, for transferring single moieties or polychains of… read more here.
Keywords: genome stability; enzymes genome; ubiquitin ubl; pulling strings ... See more keywords
Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64402-1
Abstract: Acetylation of lamin A/C by the non-specific lethal complex, containing MOF and KANSL2, is instrumental for maintaining nuclear architecture and genome stability, but the mechanisms controlling expression of its components in different cell types are… read more here.
Keywords: muscle; stem; stem cells; muscle stem ... See more keywords
SLX4: multitasking to maintain genome stability
Sign Up to like & getrecommendations! Published in 2018 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2018.1488803
Abstract: Abstract The SLX4/FANCP tumor suppressor has emerged as a key player in the maintenance of genome stability, making pivotal contributions to the repair of interstrand cross-links, homologous recombination, and in response to replication stress genome-wide… read more here.
Keywords: genome stability; slx4 multitasking; maintain genome; multitasking maintain ... See more keywords
Ribonucleotide Incorporation by Eukaryotic B-family Replicases and Its Implications for Genome Stability.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-032620-110354
Abstract: Our current view of how DNA-based genomes are efficiently and accurately replicated continues to evolve as new details emerge on the presence of ribonucleotides in DNA. Ribonucleotides are incorporated during eukaryotic DNA replication at rates… read more here.
Keywords: family; biochemistry; genome stability; ribonucleotide incorporation ... See more keywords
Maternal DCAF2 is crucial for maintenance of genome stability during the first cell cycle in mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.206664
Abstract: ABSTRACT Precise regulation of DNA replication and genome integrity is crucial for gametogenesis and early embryogenesis. Cullin ring-finger ubiquitin ligase 4 (CRL4) has multiple functions in the maintenance of germ cell survival, oocyte meiotic maturation,… read more here.
Keywords: dcaf2; genome stability; cell cycle; dna ... See more keywords
Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.215525
Abstract: ABSTRACT Dysregulation of the homeostatic balance of histone H3 di- and tri-methyl lysine 27 (H3K27me2/3) levels caused by the mis-sense mutation of histone H3 (H3K27M) is reported to be associated with various types of cancers.… read more here.
Keywords: genome stability; fancd2 chromatin; histone; h3k27me2 ... See more keywords